{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:25:38Z","timestamp":1761845138878,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracardiac rhabdomyoma is an uncommon benign striated muscle tumor with a predilection for the head and neck region. However, it is extremely rare for extracardiac rhabdomyoma to present as a thyroid nodule. We report a case of rhabdomyoma diagnosed by thyroid fine\u2010needle aspiration (FNA) in a patient with Birt\u2010Hogg\u2010Dub\u00e9 (BHD) syndrome. A 60\u2010year\u2010old man with BHD syndrome presented for recurrent pneumothorax. Chest CT incidentally identified a thyroid nodule. Subsequent sonography confirmed a 4.44\u2009\u00d7\u20092.28\u2009\u00d7\u20092.82\u2009cm solid, hypoechoic nodule with smooth margins in the right upper pole. Ultrasound\u2010guided FNA revealed many clusters and scattered isolated large polygonal cells with abundant granular cytoplasm and small peripherally located nuclei. Vague striations in the cytoplasm were focally identified. No follicular cells or colloid was present. Immunocytochemistry on one direct smear slide demonstrated diffuse positivity for desmin, supporting muscular differentiation. Subsequent surgery identified an adult rhabdomyoma originating from the inferior constrictor muscle of the neck and anteriorly displacing the thyroid. Because the mass was intimately associated with the thyroid gland, it was initially mistaken for a thyroid nodule on ultrasound. Diagnosis of rhabdomyoma on FNA is challenging, especially when rhabdomyoma mimics a thyroid nodule on imaging. The differential diagnosis includes Hurthle cell neoplasm, granular cell tumor, colloid nodule, and normal striated skeletal muscle. Adequate radiologic data and familiarity with the cytologic features of rhabdomyoma are critical for an accurate diagnosis.<\/jats:p>","DOI":"10.1002\/dc.24413","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T21:16:06Z","timestamp":1584566166000},"page":"576-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adult rhabdomyoma presenting as thyroid nodule on fine\u2010needle aspiration in patient with Birt\u2010Hogg\u2010Dub\u00e9 syndrome: Case report and literature review"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-0065","authenticated-orcid":false,"given":"Margaret","family":"Black","sequence":"first","affiliation":[{"name":"Department of Pathology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Simms","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Negron","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R.","family":"Chidakel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Hodak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Persky","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4580-7556","authenticated-orcid":false,"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80198-8"},{"key":"e_1_2_6_3_1","first-page":"142","volume-title":"Tumours of Soft Tissue and Bone: Pathology & Genetics","author":"Kapadia SB","year":"2002"},{"key":"e_1_2_6_4_1","first-page":"359","article-title":"Sternomastoid rhabdomyoma mimicking a thyroid nodule","volume":"81","author":"Adickes ED","year":"1996","journal-title":"Neb Med J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326364"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027589"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840040216"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10241"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23860"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21530"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21033"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060513"},{"key":"e_1_2_6_13_1","unstructured":"CraneJS RuttV OakleyAM. Birt Hogg Dube Syndrome. StatPearls[internet]. NCBI web site.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK448061\/"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0922-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.4205.1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36917"},{"key":"e_1_2_6_17_1","first-page":"753694","article-title":"A rare soft tissue tumor masquerading as a parathyroid adenoma in a patient with Birt\u2010Hogg\u2010Dub\u00e9 syndrome and multiple cervical endocrinopathies","volume":"2014","author":"Mikesell KV","year":"2014","journal-title":"Case Rep Pathol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.054304"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.24413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:13:55Z","timestamp":1694009635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/dc.24413"],"URL":"https:\/\/doi.org\/10.1002\/dc.24413","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"2020-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}