{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:28:36Z","timestamp":1771302516198,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The standard screening test for detecting cervical lesions and cancers is a Papanicolaou (Pap) smear. While squamous cell abnormalities remain the most common positive Pap test result, cytologic findings of glandular cell abnormalities have become more frequent in recent decades. The 2014 Bethesda System for reporting cervical cytology includes the classification \u201catypical glandular cells\u201d (AGC). AGC have morphological abnormalities that fall outside the range of reactive changes, but are insufficient for a diagnosis of invasive adenocarcinoma. In several histologic follow\u2010up studies, most AGC cases were found to represent a benign condition. In the current study, we evaluate the significance of AGC cytology findings by analyzing the histologic follow\u2010up results of a large number of patients with AGC. Most patients with AGC in this study were found to have a significant lesion on follow\u2010up (63.9%), with negative histologic results in only 36.1% of patients. Among patients with significant lesions, the most common result was low\u2010grade squamous intraepithelial lesion (26.6%), followed by high\u2010grade squamous intraepithelial lesion (23.2%). This provides further evidence to support the Chilean Clinical Guidelines for Cervical Cancer, which recommends diagnostic follow\u2010up studies in all women with AGC to minimize the chance of undetected serious cervical disease.<\/jats:p>","DOI":"10.1002\/dc.24421","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T08:21:32Z","timestamp":1585815692000},"page":"852-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytohistological correlation in patients with atypical glandular cells on Papanicolaou test in a Chilean population"],"prefix":"10.1002","volume":"48","author":[{"given":"Daniela","family":"Gonz\u00e1lez\u2010Espinoza","sequence":"first","affiliation":[{"name":"Preventive Oncology Center, Faculty of Medicine University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ponce Camus","sequence":"additional","affiliation":[{"name":"Preventive Oncology Center, Faculty of Medicine University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ives","family":"Meneses P\u00e9rez","sequence":"additional","affiliation":[{"name":"Preventive Oncology Center, Faculty of Medicine University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-7506","authenticated-orcid":false,"given":"Carla","family":"Molina Cruz","sequence":"additional","affiliation":[{"name":"Preventive Oncology Center, Faculty of Medicine University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0231"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"645","article-title":"Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix\u2010worldwide","volume":"10","author":"Mathew A","year":"2009","journal-title":"Asian Pacific J Cancer Prev"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3385"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-0009.2011.00652.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5826"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302011000200024"},{"issue":"143","key":"e_1_2_7_8_1","first-page":"1","article-title":"Cancer incidence in five continents","volume":"8","author":"Parkin D","year":"2002","journal-title":"IARC Sci Publ"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11074-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5468\/OGS.2013.56.2.76"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21724"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325117"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017070"},{"issue":"4","key":"e_1_2_7_14_1","first-page":"266","article-title":"Atypical glandular cells of undetermined significance. 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