{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:25:49Z","timestamp":1774682749570,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic large cell lymphoma (ALCL) is a non\u2010Hodgkin lymphoma of T\u2010cell or null\u2010cell lineage with variable cytomorphology. We report two rare ALCL cases with carcinomatous and sarcomatous patterns, respectively, in fine needle aspiration (FNA) cytology and histopathology. The first case was a 56\u2010year\u2010old man with enlarged left inguinal lymph node. FNA smears showed a malignant small round cell tumor with nuclear molding. In addition, there were large bi\u2010nucleated and multinucleated cells with wreath\u2010like arrangement of nuclei. ALCL and small cell (neuroendocrine) carcinoma were the possibilities considered. Immunocytochemical studies on FNA smears showed positive reaction for leukocyte common antigen (LCA) and negative results for cytokeratin (CK) and chromogranin. Histopathological examination of the lymph node showed features of ALCL with following immunohistochemical staining results: LCA+, CD30+, CD45RO+, CD20\u2212, CD3+ (weak), and Alk1\u2212. During review of sections, areas resembling a small cell anaplastic carcinoma were observed. The second case was a 24\u2010year\u2010old woman with right cervical lymphadenopathy. FNA smears showed an ALCL with highly atypical large cells including bi\u2010nucleated and donut shaped cells, which were positive for CD30, EMA, and Alk\u20101 protein, and negative for CD20, CD3, and CK. Histopathological examination corroborated the cytodiagnosis of ALCL, and with positive immunohistochemical staining for CD30, EMA, Alk\u20101 protein+, BCL6+, and Ki67+ (40% cells) and negative results for CD20, CD10, CD3, CD5, CD15, BCl2, CD79a, and CD68. Sarcomatous components were noticed during review of cytologic and histopathological specimen. Awareness about these unusual cytomorphological patterns in ALCL may be of help in proper diagnosis of this neoplasm.<\/jats:p>","DOI":"10.1002\/dc.24477","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T15:24:21Z","timestamp":1591197861000},"page":"1115-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anaplastic large cell lymphoma: Report of two cases with rare patterns (carcinomatous and sarcomatous) in fine needle aspiration cytology and histopathology"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8340-9220","authenticated-orcid":false,"given":"Dilip K.","family":"Das","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pathology Kuwait University  Safat Kuwait"},{"name":"Cytology Unit Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-4202","authenticated-orcid":false,"given":"Mrinmay K.","family":"Mallik","sequence":"additional","affiliation":[{"name":"Cytology Unit Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah E.","family":"Ali","sequence":"additional","affiliation":[{"name":"Histopathology Unit Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemah ASK","family":"Khadom","sequence":"additional","affiliation":[{"name":"Cytology Unit Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bency","family":"John","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pathology Kuwait University  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoun","family":"Al\u2010Ayanti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pathology Kuwait University  Safat Kuwait"},{"name":"Histopathology Unit Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0295-CC"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.208101"},{"key":"e_1_2_6_4_1","first-page":"312","volume-title":"WHO Classification of Tumours of the Hematopoietic and Lymphoid Tissues","author":"Delsol G","year":"2008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23120"},{"key":"e_1_2_6_6_1","first-page":"317","volume-title":"WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues","author":"Mason DY","year":"2008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880289"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23290"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21552"},{"key":"e_1_2_6_10_1","first-page":"247","article-title":"Anaplastic large cell lymphoma: a cytological masquerade","volume":"3","author":"Chhabra S","year":"2015","journal-title":"Am J Med Case Rep"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333958"},{"key":"e_1_2_6_12_1","first-page":"309","article-title":"Fine\u2010needle aspiration (FNA) cytology diagnosis of small round cell tumors: value and limitations","volume":"47","author":"Das DK","year":"2004","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.86362"},{"key":"e_1_2_6_14_1","first-page":"292","article-title":"Breast carcinoma with neuroendocrine differentiation: diagnosis of a case by fine needle aspiration and immunocytochemistry","volume":"48","author":"Das DK","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199803)18:3<179::AID-DC3>3.0.CO;2-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21372"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324972"},{"key":"e_1_2_6_18_1","first-page":"508","article-title":"Cytologic findings in the sarcomatoid variant of large cell anaplastic (Ki\u20101) lymphoma. 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