{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:08:36Z","timestamp":1759741716571,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Worldwide, endometrial carcinoma is one of the most frequently diagnosed cancers among women and a considerable cause of death. The aims of this study were to determine the expression of cyclooxygenase\u20102 (COX\u20102) in endometrial adenocarcinoma in imprint smears as an alternative technique and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred twenty\u2010six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29\u2010month period. The cytologic imprint smears were obtained by touching the cut surface of cancer tissues and the expression of COX\u20102 was assessed by immunocytochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positive expression of COX\u20102 in malignant cells, was accompanied by morphologic features of more aggressiveness (pathogenetic type II, advanced clinical stage, mainly high grade, deep myometrial involvement &gt;1\/2) tumors and the affected from the disease lymph nodes cases showed higher positivity (41.2%) than the non\u2010affected (13.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Immunocytochemical findings from COX\u20102 stain in cancer cells could be a predictor of prognosis in most cases in endometrial cytology with imprint smears. Furthermore, positive expression of COX\u20102 in cancer cells was related to morphologic features of more aggressiveness tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24481","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T19:54:13Z","timestamp":1590004453000},"page":"1086-1092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of cyclooxygenase\u20102 in imprint smears of endometrial carcinoma"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-8935","authenticated-orcid":false,"given":"Konstantinos","family":"Kosmas","sequence":"first","affiliation":[{"name":"Department of Cytopathology General Chest Diseases Hospital of Athens \u201cSOTIRIA\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Mitropoulou","sequence":"additional","affiliation":[{"name":"Department of 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