{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T05:28:38Z","timestamp":1749187718672,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2\u2009years were reviewed. Frequency analysis and correlations between the diagnostic tools were established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co\u2010infections occurred in 429 (54.7%) and the most frequently identified types were HPV\u20106, HPV\u201042, and HPV\u201016, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive\/negative predictive values of peniscopy, cytology, and histopathology were 83\/31%, 92\/32%, and 87\/33%, respectively. As a result, though significant, the correlations between genotype and non\u2010molecular tests were poor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co\u2010infections. Though significant, its correlation with non\u2010molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24518","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T09:23:39Z","timestamp":1591262619000},"page":"1021-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males"],"prefix":"10.1002","volume":"48","author":[{"given":"Jose Carlos","family":"Truzzi","sequence":"first","affiliation":[{"name":"Division of Urology\u2014Fleury Group Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael Dale","family":"da Silva","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Department of Gynecology\u2014Fleury Group Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Paulo","family":"Freire","sequence":"additional","affiliation":[{"name":"Division of Urology Universidade Anhembi Morumbi  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Jorge","family":"Neto","sequence":"additional","affiliation":[{"name":"Division of Urology\u2014Fleury Group Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Ferro","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Division of Urology\u2014Fleury Group Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Arantes","family":"Maciel","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology\u2014Fleury Group Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruana","family":"Girardi","sequence":"additional","affiliation":[{"name":"Division of Urology Universidade Anhembi Morumbi  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sissi","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Division of Urology Universidade Anhembi Morumbi  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-414X","authenticated-orcid":false,"given":"Leonardo O.","family":"Reis","sequence":"additional","affiliation":[{"name":"Division of UroScience University of Campinas and Pontifical Catholic University of Campinas  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/507432"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0151"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-117"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00013-15"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0070(88)90023-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.3.2013.1.9"},{"key":"e_1_2_9_8_1","unstructured":"Greiner Bio\u2010One GmbH. 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