{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:50:20Z","timestamp":1785927020904,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic thyroid lesions represent one of the most common causes of unsatisfactory fine\u2010needle aspiration sampling. Thus, it is important to access the maximum number of follicular cells from cystic fluid in order to reduce unsatisfactory rates. We compared the traditional method of smearing with an alternative one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For each thyroid nodule, two smears were collected. Each smear was prepared using a distinct approach: either using the traditional technique or the alternative. Clinical data were taken from cytopathological request forms. The cytological aspects of the smears (eg, adequacy and number of cells) were observed during microscopy analysis. No cases were found to be suspicious for malignancy during ultrasound analysis (categories TR1 or TR2 according to ACR TI\u2010RADS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five cases were analyzed. For smears prepared using both the traditional and the alternative techniques, 20 and 4 cases, respectively, were unsatisfactory. In the 20 unsatisfactory traditional smear cases, 9 (45%) showed enough cells for diagnosis in cytospin and\/or cell block samples; the four unsatisfactory alternative method cases showed the same. There was a statistical difference between the two methods of collecting a smear concerning sample adequacy (<jats:italic>P<\/jats:italic> &lt;\u2009.001), but there was no statistical difference regarding the cellularity (<jats:italic>P<\/jats:italic> =\u2009.842).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our data, the alternative method of using only one slide and the needle tip had higher rates of adequate sampling. Since it is cost effective and does not change the cytological analysis, this proposed alternative method can be useful in cases of cystic thyroid lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24525","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T14:40:33Z","timestamp":1592232033000},"page":"1054-1057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An alternative method for smear preparation of fine\u2010needle aspiration cytology of cystic thyroid lesions: Evaluation of sample adequacy"],"prefix":"10.1002","volume":"48","author":[{"given":"Jos\u00e9 C\u00e2ndido Caldeira","family":"Xavier\u2010J\u00fanior","sequence":"first","affiliation":[{"name":"Pathology Institute of Ara\u00e7atuba  Ara\u00e7atuba S\u00e3o Paulo Brazil"},{"name":"School of Medicine Centro Universit\u00e1rio Cat\u00f3lico Unisalesiano Auxilium  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Jos\u00e9 Pizzello","family":"Zogheib","sequence":"additional","affiliation":[{"name":"Pathology Institute of Ara\u00e7atuba  Ara\u00e7atuba S\u00e3o Paulo Brazil"},{"name":"School of Medicine Centro Universit\u00e1rio Cat\u00f3lico Unisalesiano Auxilium  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deolino Jo\u00e3o","family":"Camilo\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Pathology Institute of Ara\u00e7atuba  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange Correa Garcia Pires","family":"D'\u00e1villa","sequence":"additional","affiliation":[{"name":"Pathology Institute of Ara\u00e7atuba  Ara\u00e7atuba S\u00e3o Paulo Brazil"},{"name":"Department of Pathology S\u00e3o Jos\u00e9 do Rio Preto Medical School (FAMERP)  S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neivio Jos\u00e9","family":"Mattar","sequence":"additional","affiliation":[{"name":"Pathology Institute of Ara\u00e7atuba  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60570-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.55"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333893"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0082"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326712"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381412"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840010114"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-1433-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2446-7"},{"key":"e_1_2_8_11_1","volume-title":"Fine Needle Aspiration Cytology. 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