{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:15:14Z","timestamp":1769163314113,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Urine cytology evaluation is an effective test in the detection of high\u2010grade urothelial carcinoma (HGUC). While the guideline distinguishes the 2 categories: \u201cpositive for HGUC\u201d (PHGUC) and \u201csuspicious for HGUC\u201d (SHGUC), the association between these categories with their subsequent follow\u2010up biopsies remains unclear. This study aims to determine and compare the positive predictive value (PPV) of the specimens in PHGUC and SHGUC categories with their respective histologic diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the period of 03\/01\/2008 to 07\/31\/2018, urine cytology cases diagnosed as PHGUC and SHGUC with subsequent bladder biopsy within 12 months were retrieved. All cases were correlated with first biopsy obtained during 12 months of cytology specimen. Biopsy result with HGUC, carcinoma in situ, or non\u2010urothelial carcinoma diagnoses were considered as concordance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>378 cases (229 SHGUC and 149 PHGUC) were identified from 263 patients. For the 229 SHGUC cases, the PPV was 72% (n = 166) and for the 149 PHGUC cases, the PPV was 85% (n = 127). While both categories have high PPV, they are statistically significant (<jats:italic>p<\/jats:italic> &lt; 0.0001). Additionally, 33 cases were found to have low\u2010grade urothelial carcinoma (LGUC), constituting a portion of discordant results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PHGUC and SHGUC categories are both associated with a high risk of malignancy, however, there is a statistically significant difference between them in our study, supporting the PSRUC guidelines of two separate categories. In instances when urine cytology is discordant with biopsy results, further investigation and clinical follow up is warranted. LGUC appears to remain a common pitfall especially in the suspicious category.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24531","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T17:22:40Z","timestamp":1592500960000},"page":"998-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The predictive value of positive and suspicious urine cytology: Are they different?"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-2179","authenticated-orcid":false,"given":"Kevin C.","family":"Kuan","sequence":"first","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila E.","family":"Segura","sequence":"additional","affiliation":[{"name":"Indiana University\/School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Ahlstedt","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham\/School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer N.","family":"Khader","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh","family":"Hakima","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13345"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4863.197258"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23119"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22864-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10401"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/cytojournal.cytojournal_12_17"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23639"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21735"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21958"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481278"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21449"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21764"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21254"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12448"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12505"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2610"},{"issue":"5","key":"e_1_2_8_19_1","first-page":"7739","article-title":"Combined use of urinary Survivin detection and liquid\u2010based cytology for the early diagnosis of bladder urothelial carcinoma","volume":"15","author":"Xu X","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2015.08.005"}],"container-title":["Diagnostic 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