{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:01:23Z","timestamp":1774929683233,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>South Africa has a very high prevalence of HIV\/AIDS. Salivary gland lesions are common in HIV\u2010infected patients. The aim of this study was to determine the pathologic entities diagnosed on fine\u2010needle aspiration (FNA) of salivary gland masses in an HIV\u2010infected study population that now has free access to antiretroviral (ARV) therapy and how this differs from the pathologic entities before the advent of widespread ARV availability, and if the Milan system for reporting salivary gland cytopathology (MSRSGC) can be applied to HIV\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed on confirmed HIV\u2010infected patients who underwent FNA of salivary gland masses over a two\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 360 patients underwent FNA of salivary gland masses within the designated time frame, 58.3% (210) females and 41.7% (150) males. Patient ages ranged from 7\u2009months to 67\u2009years with a mean age of 36.9\u2009years. The parotid gland was the most biopsied salivary gland at 55.3% (199). The most common diagnosis made in patients on antiviral therapy was lymphoepithelial cyst while that in patients not on antiviral therapy was infectious (including abscess and mycobacterial infection). The most frequent neoplasms were non\u2010Hodgkin lymphoma, pleomorphic adenoma and squamous\u2010cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients on ARV therapy had higher CD4 counts, fewer infectious lesions, and more reactive and benign salivary gland lesions. Patients not on treatment had significantly lower CD4 counts and were frequently diagnosed with infectious processes. The MSRSGC is well\u2010suited for use in HIV\u2010infected patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24546","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T18:24:52Z","timestamp":1595355892000},"page":"1217-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of antiretroviral therapy on fine\u2010needle aspiration of salivary gland masses in <scp>HIV<\/scp>\u2010infected patients"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-9459","authenticated-orcid":false,"given":"Amanda Ama","family":"Coleman\u2010Eghan","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Health Sciences University of the Witwatersrand and National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-4277","authenticated-orcid":false,"given":"Pamela","family":"Michelow","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Health Sciences University of the Witwatersrand and National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080109"},{"key":"e_1_2_7_3_1","unstructured":"Salivary Gland Lesions in Human Immunodeficiency Virus. Medical library online Web sitewww.medicallibraryonline.com.Accessed May 16 2016."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2007.0008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26776"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Fine\u2010needle aspiration cytology in the diagnosis of parotid lesions","volume":"31","author":"Piccioni LO","year":"2011","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_7_7_1","first-page":"100","article-title":"Review of fine\u2010needle aspiration cytology of salivary gland neoplasms, with emphasis on differential diagnosis","volume":"118","author":"Perkins Mukunyadzi MD","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488969"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-71285-7_1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21597"},{"key":"e_1_2_7_11_1","unstructured":"South African Department of Health 2015.National consolidated guidelines for prevention of mother\u2010to child transmission of HIV and the management of HIV in children adolescents and adults.www.sahivsoc.org. ."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4102\/sajhivmed.v13i3.125"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4102\/sajhivmed.v15i4.330"},{"key":"e_1_2_7_14_1","first-page":"400","article-title":"HIV associated salivary gland enlargement: a clinical review","volume":"69","author":"Ebrahim S","year":"2014","journal-title":"SADJ"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"1","article-title":"Hiv and lymphoma: from epidemiology to clinical management","volume":"11","year":"2019","journal-title":"Mediterranean journal of hematology and infectious diseases"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23780"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-016-0318-8"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.24546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:24:24Z","timestamp":1693869864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/dc.24546"],"URL":"https:\/\/doi.org\/10.1002\/dc.24546","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"2019-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}