{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:15:58Z","timestamp":1760267758474,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor characterized by <jats:italic>WWTR1\u2010CAMTA1<\/jats:italic>, t (1:3) (p36;q25) translocation in 90% of cases. Without prior EHE history, it can mimic other malignant effusions. Recently, CAMTA1 was published as an excellent immunohistochemical surrogate marker for molecular testing for <jats:italic>WWTR1\u2010CAMTA1<\/jats:italic> fusion in surgical specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 6\u2010year retrospective search using our computer system was performed for cases diagnosed as EHE on effusion cytology and surgical specimens. The clinical presentation, cytologic findings and immunohistochemical stain results, including CAMTA1 were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four pleural and one peritoneal effusions were identified. The median age was 52\u2009years with a female to male ratio of 3:2. Most patients presented with pulmonary symptoms. The cytologic features were non\u2010specific easily mimicking other malignancies; especially in the absence of known prior malignancy. This was exemplified by one of our cases which was initially misdiagnosed as adenocarcinoma. Intracytoplasmic erythrocytes were present only on the cell blocks but not on cytology. The cytology cell blocks from patients with prior EHE confirmed on surgical biopsies stained positive for vascular markers (CD31, ERG) and CAMTA1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The features of EHE in effusion are non\u2010specific and a diagnostic pitfall in cytology. In the absence of prior EHE diagnosis, inclusion of this entity in the differential diagnoses and application of immunohistochemical stain panels will be prudent in avoiding a misdiagnosis. However, in cases with prior EHE diagnosis, CAMTA1 could serve as diagnostic marker; especially on limited cytology material. Additional studies will be helpful in supporting our results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24565","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T05:20:40Z","timestamp":1597468840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cytologic features and immunohistochemical findings of epithelioid hemangioendothelioma (<scp>EHE<\/scp>) in effusion: A case series"],"prefix":"10.1002","volume":"49","author":[{"given":"Judith","family":"Jebastin Thangaiah","sequence":"first","affiliation":[{"name":"Cleveland Clinic, Robert J. Tomsich Pathology and Laboratory Medicine Institute  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Hanley","sequence":"additional","affiliation":[{"name":"Department of Pathology CORPath, Ltd.  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Nomani","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-1964","authenticated-orcid":false,"given":"Maria Luisa","family":"Policarpio\u2010Nicolas","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Robert J. Tomsich Pathology and Laboratory Medicine Institute  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"volume-title":"Epithelioid Haemangioendothelioma","year":"2019","author":"Rubin BP","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830201)51:3<452::AID-CNCR2820510317>3.0.CO;2-M"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820901)50:5<970::AID-CNCR2820500527>3.0.CO;2-Z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002409"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20886"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12697"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000511"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-131"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840110115"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130112"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2014.12.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/cytojournal.cytojournal_46_17"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21818"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24162"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800065"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318206b67b"},{"key":"e_1_2_6_19_1","first-page":"342","volume-title":"Practical Soft Tissue Pathology: A Diagnostic Approach","author":"Hornick JL","year":"2018"},{"key":"e_1_2_6_20_1","first-page":"156","volume-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Goldblum JR","year":"2020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0368-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800986"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199704000-00001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12298"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.24565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:57:42Z","timestamp":1693810662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/dc.24565"],"URL":"https:\/\/doi.org\/10.1002\/dc.24565","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"2020-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}