{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:35:13Z","timestamp":1788838513888,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201812076"],"award-info":[{"award-number":["SZSM201812076"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) is a minimally invasive technique for cytological and histological diagnosis. The objective of this study was to explore the role of cytological diagnosis in EBUS\u2010TBNAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight hundred and thirteen consecutive cases performed EBUS\u2010TBNA with both cytological and histological diagnoses were retrospectively reviewed. All patients were followed up for clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before immunohistochemical examination, the cytological sensitivity, specificity, and diagnostic accuracy of EBUS\u2010TBNAs were 92.9% (421\/453), 98.9% (348\/352), 95.5% (769\/805), respectively. After immunohistochemical examination, the sensitivity, specificity, and diagnostic accuracy were 93.0% (423\/455), 99.4% (348\/350), 95.8% (771\/805), respectively. The majority of false\u2010negative were cases whose cytological diagnosis was \u201catypical\u201d or the cytological diagnosis suggested \u201cinadequate.\u201d \u201cNeoplastic\u201d were also prone to false\u2010negative cytology. The diagnostic accordance rate of cytological subtyping was 90.3% for squamous\u2010cell carcinoma, 99.2% for adenocarcinoma, and 98.1% for small\u2010cell carcinoma before immunohistochemical examination, and became 85.9%, 98.5%, and 98.2% after immunohistochemical examination, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cytological diagnosis in EBUS\u2010TBNAs had a good sensitivity and high specificity. The sensitivity and specificity of cytological diagnosis were proved to be higher after the immunohistochemical examination. At the same time, cytology had high accordance rate in subtype diagnosis. False\u2010negative results occurred more commonly in cases whose cytological diagnosis was \u201catypical\u201d or the cytological diagnosis suggested \u201cinadequate\u201d or the corresponding histological diagnosis was \u201cNeoplastic.\u201d<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24608","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T08:48:30Z","timestamp":1601196510000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of cytology in endobronchial <scp>ultrasound\u2010guided<\/scp> transbronchial needle aspiration: A study of 813 cases focusing on diagnostic yield, an analysis of misdiagnosed cases and diagnostic accordance rate of cytological subtyping"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-0541","authenticated-orcid":false,"given":"Wen\u2010hao","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Pathology and Resident Training Base, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Mei","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Resident Training Base, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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