{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:18:39Z","timestamp":1788866319408,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mixed medullary and follicular cell\u2010derived thyroid carcinoma (MMFTC) is a rare primary thyroid carcinoma with morphologic and immunophenotypic evidence of admixed parafollicular and follicular cell\u2010derived tumor populations within the same tumor. We herein present the fine\u2010needle aspiration biopsy (FNAB) cytology of a case of MMFTC that was diagnosed histologically and discuss potential clues to the diagnosis for cytologists. We also provide a literature review of this uncommon primary thyroid tumor. The patient was a 47\u2010year\u2010old man with a history of hypothyroidism who presented with ear and neck pain. Imaging demonstrated thyroid nodules with regional lymphadenopathy. FNAB samples of two thyroid nodules and an involved lymph node were diagnosed as papillary thyroid carcinoma (PTC). The subsequent total thyroidectomy specimen demonstrated classic\u2010type PTC which transitioned to a morphologically and immunophenotypically distinct medullary thyroid carcinoma (MTC) component within the same lesion, indicative of MMFTC. The patient experienced recurrence of the medullary component 20 months later and received chemotherapy with subsequent external beam radiation. As in this case, the cytologic diagnosis of MMFTC is almost never made prospectively. Retrospective review of the preoperative FNAB samples showed subtle cytomorphologic features suggestive of MTC in two of three biopsies, an impression confirmed by calcitonin immunohistochemistry on cell block material. In the broader literature, most MMFTCs on FNAB have been diagnosed as MTC, which is usually the more aggressive component of the mixed neoplasm.<\/jats:p>","DOI":"10.1002\/dc.24615","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:59:23Z","timestamp":1600293563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cytologic features of a case of mixed medullary and follicular <scp>cell\u2010derived<\/scp> thyroid carcinoma with review of the literature"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-0509","authenticated-orcid":false,"given":"Meagan","family":"Chambers","sequence":"first","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Tafe","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"},{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3392-4731","authenticated-orcid":false,"given":"Edward J.","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"},{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-2044","authenticated-orcid":false,"given":"Darcy A.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"},{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Pathology and Genetics of Tumours of Endocrine Organs","author":"International Agency for Research on Cancer","year":"2004"},{"key":"e_1_2_8_3_1","first-page":"114","volume-title":"WHO Classif Tumours Endocr Glands","author":"Volante M","year":"2017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2357-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1991.1.249"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00627008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078576"},{"key":"e_1_2_8_8_1","first-page":"1561","article-title":"Mixed medullary and papillary thyroid carcinoma: a stepwise diagnosis","volume":"21","author":"Myoteri D","year":"2016","journal-title":"J BUON"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2010.11680605"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181e4ab3e"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.142684"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.141520"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-019-09603-3"},{"key":"e_1_2_8_14_1","first-page":"148","article-title":"Simultaneous occurrence of medullary and differentiated thyroid carcinomas. 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