{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:34:36Z","timestamp":1751438076802,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Background<\/jats:title><jats:sec><jats:label\/><jats:p>Lymphomas presenting in effusions could either be primary or secondary, with very limited data from Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed effusion lymphomas from our archives in a tertiary center from July 2011 to June 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 59 specimens from 43 patients, including 7 cases with primary effusion lymphoma (PEL) and 36, secondary effusion involvement. Half of the secondary cases presented concurrently with effusion lymphoma, while the remaining half\u2010experienced effusion lymphoma during disease progression. All patients with PELs were males with a median age of 77 and presented with massive pleural effusion. None was HIV\u2010related. Two (29%) PEL cases were positive for human herpes virus 8 (HHV8). The only case with plasmablastic phenotype in the PEL group was positive for both HHV8 and EBV. Four patients died shortly after diagnosis; while the remaining three were alive at the last follow\u2010up (two at 13\u2009months and one at 99\u2009months). Of the secondary cases, diffuse large B\u2010cell lymphoma\/high grade B\u2010cell lymphoma was the most common (n = 16, 44%), followed by mantle cell lymphoma (n = 5, 14%). Only 8 cases (22%) were T\u2010cell neoplasms. Prognosis for patients with secondary effusion involvement was dismal, with 1\u2010 and 2\u2010year overall survival rates at 17% and 8%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a wide cytopathological spectrum of effusion lymphoma in Taiwan. Most of our PEL cases were distinct from that defined in the World Health Organization scheme by a B\u2010cell phenotype, HHV8\u2010negativity, and absence of immunodeficiency. As compared to PEL cases, the prognosis of those with secondary involvement was extremely poor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24626","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T13:28:09Z","timestamp":1601040489000},"page":"232-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The cytopathological spectrum of lymphomas in effusions in a tertiary center in Taiwan"],"prefix":"10.1002","volume":"49","author":[{"given":"Ren Ching","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Nursing, College of Nursing HungKuang University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory 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