{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T07:44:58Z","timestamp":1750664698622,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cervical cancer screening algorithms are increasingly focused on Human Papillomavirus (HPV)\u2010based screening while the accuracy of using abnormal cytological findings to detect dysplastic lesions still remains important. This retrospective study correlated the results of conventional cervical cytology, colposcopy guided biopsy, and cold knife conization (CKC) procedures performed in a tertiary center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data from 9399 patients who underwent screening with conventional cervical cytology between 2010 and 2019 was obtained from the hospital registry. Abnormal cervical cytology and high\u2010risk HPV DNA genotypes were recorded and their colposcopic and CKC pathology was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and ninety two patients underwent colposcopy for abnormal cervical cytology and\/or high\u2010risk HPV positivity. One hundred and twenty three patients were positive for High\u2010risk HPV. Abnormal cervical cytology was detected in 216 patients. The most common cytological anomaly was atypical squamous cells of undetermined significance (ASCUS) found in 9399 patients (1.39%). It was determined that conventional cytology had a sensitivity of 70.8% and a specificity of 62.2% for the detection of low\u2010grade lesions, while it had a sensitivity of 72.4% and a specificity of 86.0% for the detection of high\u2010grade lesions. CKC was applied to 68 patients who were diagnosed with high\u2010grade squamous intraepithelial lesions (HSIL) as a result of the colposcopy. As a result of CKC, a high\u2010grade lesion was detected in 73.5% of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conventional cervical cytology and colposcopy exhibited higher accuracy as the severity of lesions increased. Detection of HPV may prevent unnecessary surgical procedures, especially with ASCUS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24655","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:29:21Z","timestamp":1603970961000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Concordance of<scp>HPV<\/scp>, conventional smear, colposcopy, and conization results in cervical dysplasia"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-8214","authenticated-orcid":false,"given":"Demet","family":"Aydogan Kirmizi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Yozgat Bozok University Yozgat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty 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