{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:52:30Z","timestamp":1747147950164,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to determine the association between preoperative cytopathological diagnosis and the histopathological diagnosis of orofacial non\u2010odontogenic tumors. It is also, to determine the sensitivity, specificity and accuracy of fine needle aspiration cytology (FNAC) in the preoperative diagnosis of orofacial malignant non\u2010odontogenic tumors in a Nigerian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 9\u2010month prospective study in which preoperative FNAC followed by open biopsy for confirmatory histopathological evaluation was performed for consenting patients with orofacial swellings. Patients histopathologically diagnosed as non\u2010odontogenic tumors were selected for the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 40 (83.3%) histopathologically diagnosed non\u2010odontogenic tumors. The female to male ratio was 1.7:1 and the patients' mean age was 36\u2009+\u200921.9\u2009years. The mandible (n = 4, 10.0%) and the preauricular area (n = 4, 10.0%) were the most common sites affected. The cytopathological diagnosis showed 28 (70.0%) of the lesions were malignant, 7 (17.5%) were benign neoplasms and 5 (12.5%) were reactive\/inflammatory swellings. The histopathological diagnosis was predominantly malignant (n = 29, 72.5%), consisting mostly of non\u2010Hodgkin's lymphoma (n = 12, 30.0%). There was significant association (<jats:italic>P<\/jats:italic> = .000) between cytopathological diagnosis and histopathological diagnosis of the malignant orofacial non\u2010odontogenic tumors. The sensitivity of FNAC to detect malignant orofacial nonodontogenic tumors was 93.1%, the specificity was 90.9%, the positive predictive value was 96.4%, the negative predictive values was 83.3% and the accuracy was 92.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The accuracy of FNAC in the diagnosis of orofacial malignant non\u2010odontogenic orofacial tumors is high and hence recommended as a routine preoperative diagnostic tool.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24665","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T16:01:43Z","timestamp":1605542503000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accuracy of fine needle aspiration cytology in the preoperative diagnosis of malignant non\u2010odontogenic tumors of the orofacial region"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-0444","authenticated-orcid":false,"given":"Dickson Sopuru","family":"Okoh","sequence":"first","affiliation":[{"name":"Department of Dental and Maxillofacial Surgery Federal Medical Centre  Asaba Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix Osawe","family":"Omoregie","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Medicine University of Benin  Benin City Edo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike Akin","family":"Ojo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Medicine University of Benin  Benin City Edo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"367","article-title":"Clinicopathologic study of 142 orofacial tumor in children and adolescents in southern Iran","volume":"21","author":"Zohreb JA","year":"2011","journal-title":"Iran J Paediatr"},{"key":"e_1_2_7_3_1","first-page":"3","article-title":"Orofacial tumors and tumor\u2010like lesions in Kano, Nigeria","volume":"5","author":"Arotiba JT","year":"2003","journal-title":"The Nig J Surg Res"},{"issue":"4","key":"e_1_2_7_4_1","article-title":"Tumours and tumor\u2010like lesions of the lower face at Korle Bu Teaching Hospital, Ghana \u2013 an eight year study","volume":"5","author":"Parkins GEA","year":"2007","journal-title":"World J Surg Oncol"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"10","article-title":"A study of the clinicopathologic patterns of orofacial carcinomas in a Nigerian population","volume":"1","author":"Okoh DS","year":"2015","journal-title":"Afr J Oral Maxillofac Path Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(75)80038-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-7071(02)00518-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2004.tb00012.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(99)80020-1"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"247","article-title":"Fine needle aspiration cytology of soft tissue tumors with special emphasis on grading of spindle cell sarcomas","volume":"3","author":"Sharanabasav Choukimath M","year":"2012","journal-title":"IJABPT"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.83461"},{"key":"e_1_2_7_12_1","first-page":"443","article-title":"Fine Needle Aspiration biopsy of cystic lesions of head and neck, excluding the thyroid","volume":"34","author":"Djemek A","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_7_13_1","first-page":"481","article-title":"Thyroid cancer in Children and adolescents","volume":"14","author":"Degnan BM","year":"1993","journal-title":"J Pediatr Surg Pediatr Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697800"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402011000300013"},{"key":"e_1_2_7_16_1","first-page":"135","article-title":"Aspiration cytology of oral cavity and jaw bone lesion. 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