{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:56Z","timestamp":1786977596421,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Brunner's gland adenoma (hyperplasia) (BGA\/H) is a benign gastrointestinal lesion, usually asymptomatic and frequently detected incidentally by endoscopy as a submucosal nodule. Most BGA\/Hs are diagnosed by their typical cytological morphology and immunohistochemical features, characterized by monomorphic cells arranged as loosely clusters of epithelial cells with abundant, clear, and granular cytoplasm, eccentrically located nuclei, and immunoreactivity for MUC\u20106. The combination of the clinical and pathological features is essential for rendering a correct diagnosis. Herein, we report two cases of BGA\/H, including their cytologic and histologic features, and a literature review of the clinicopathologic findings along with its differential diagnoses.<\/jats:p>","DOI":"10.1002\/dc.24680","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T09:06:54Z","timestamp":1607764014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cytological diagnosis of Brunner's gland adenoma (hyperplasia): A diagnostic challenge"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-6794","authenticated-orcid":false,"given":"Domenika","family":"Ortiz Requena","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Jackson Memorial Hospital\/University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rojas","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Healthcare System\/Joe DiMaggio Children Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Garcia\u2010Buitrago","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Jackson Memorial Hospital\/University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"7565","article-title":"Brunner's gland adenoma of duodenum: report of two cases","volume":"8","author":"Lu L","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(62)90226-X"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"290","article-title":"Brunner's gland hamartomas: clinical presentation and pathological features of 27 cases","volume":"90","author":"Levine JA","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00431666"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"147","article-title":"A large Brunner's gland adenoma: an unusual cause of gastrointestinal bleeding. Case report and literature review","volume":"81","author":"Pironi D","year":"2010","journal-title":"Ann Ital Chir"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2477-18"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2017.07.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.11.036"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000454711"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02066.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.03.034"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T01:28:28Z","timestamp":1693531708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/dc.24680"],"URL":"https:\/\/doi.org\/10.1002\/dc.24680","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,12]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}