{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:52:33Z","timestamp":1747147953478,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pseudopapillary tumor (SPT) is a rare primary pancreatic neoplasm of uncertain origin and low malignant potential that typically affects young females, mostly in their third decade of life. There are only a few reports on fine needle aspiration (FNA) cytology diagnosis of this neoplasm. We report one such case which was diagnosed based on cytomorphologic and immunocytochemical features on endoscopic ultrasound (EUS) guided FNA smears. A 24\u2010year\u2010old woman presented to the gastroenterology clinic with 3\u2010month history of epigastric pain, anorexia, and weight loss (10\u00a0kg over same time period). Abdominal CT revealed a large (13X11 cm) heterogeneous cystic lesion occupying most of the pancreatic body. EUS examination confirmed the presence of a large mixed cystic\u2010solid lesion occupying most of the pancreatic body and neck. EUS\u2010guided FNA smears showed tumor cells in sheets with papillary\/pseudo\u2010papillary and acinar formation. The tumor cells had abundant clear and vacuolated cytoplasm and round to oval nuclei with bland chromatin. PAS staining revealed positively stained capillary networks at the core of the papillary\/pseudo\u2010papillary structures. In addition, there were PAS positive intra\u2010cytoplasmic and extra\u2010cellular globules which were diastase resistant. Immuno\u2010cytochemical staining on direct smears revealed positive reaction for cyclinD1, vimentin, CD56, beta\u2010catenin, CD10 and progesterone receptor. Thus, this is the example of an extremely rare neoplasm which had a typical clinical and imaging setting, and could be conclusively diagnosed because of characteristic cytomorphological and immunocytochemical features.<\/jats:p>","DOI":"10.1002\/dc.24689","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T13:31:45Z","timestamp":1609248705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Solid pseudo\u2010papillary tumor of the pancreas: Diagnosis by endoscopic ultrasound\u2010guided fine needle aspiration cytology and immunocytochemistry"],"prefix":"10.1002","volume":"49","author":[{"given":"Zafar A.","family":"Sheikh","sequence":"first","affiliation":[{"name":"Cytology Unit Mubarak Al\u2010Kabeer Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A.","family":"Alali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Haya Al\u2010Habeeb Center, Mubarak\u2010Kabeer Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemah A. S.","family":"Almousawi","sequence":"additional","affiliation":[{"name":"Cytology Unit Mubarak Al\u2010Kabeer Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8340-9220","authenticated-orcid":false,"given":"Dilip K.","family":"Das","sequence":"additional","affiliation":[{"name":"Cytology Unit Mubarak Al\u2010Kabeer Hospital  Safat Kuwait"},{"name":"Department of Pathology, Faculty of Medicine Kuwait University  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872012000900012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gou006"},{"key":"e_1_2_7_4_1","first-page":"131","article-title":"Solid\u2010papillary tumors of the pancreas: histopathology","volume":"7","author":"Santini D","year":"2006","journal-title":"J Pancreas (Online)"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.5364"},{"key":"e_1_2_7_6_1","first-page":"66","article-title":"Solid psedopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential","volume":"17","author":"Klimstra DS","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.236035006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325236"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1476"},{"key":"e_1_2_7_10_1","first-page":"210","article-title":"Cytopathology of the pancreatobiliary tract\u2013the agony, and sometimes, the ease of it","volume":"4","author":"Conrad R","year":"2013","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.138677"},{"key":"e_1_2_7_12_1","first-page":"632","article-title":"Fine needle aspiration cytology of pancreatoblastoma with immunocytochemical and ultrastructural studies","volume":"34","author":"Silverman JF","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.93810"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21403"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0072-RA"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:47:35Z","timestamp":1693399655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/dc.24689"],"URL":"https:\/\/doi.org\/10.1002\/dc.24689","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2020,12,29]]},"assertion":[{"value":"2020-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}