{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:45:49Z","timestamp":1783943149655,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human papillomavirus (HPV) is a primary risk factor for cervical cancer. HPV 16 and 18 are the two most carcinogenic genotypes and have been reported in the majority of cervical cancer. High\u2010risk HPVs (hrHPVs) other than HPV 16\/18 cause approximately a quarter of cervical cancers. We aimed to present the colposcopy\u2010guided biopsy results of non\u201016\/18 hrHPV\u2010infected women with negative cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study conducted on 752 patients between the ages of 30\u201065 years with non\u201016\/18 hrHPV and negative cytology undergoing colposcopy\u2010guided biopsy at a tertiary gynecological cancer center between January\u20102016 and January\u20102019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the women was 42.35\u00b19.41 years. Cervical intraepithelial neoplasia (CIN) 2+ lesion was detected in 49 (6.5%) women with negative cytology. The rate of CIN 2+ lesions in women with abnormal cytology was 12.8%. Patients with abnormal cytology had about 2.1 and 2.4 times increased the odds of CIN 2+ lesion in cervical biopsy and endocervical curettage specimens, respectively. CIN 3+ lesion was detected in 20 (2.7%) women with negative cytology. One (0.1%) of the patients with HPV 39 and negative cytology had invasive cervical cancer. The two most common HPV subtypes were HPV 31 and HPV 51.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of cervical preinvasive lesions still can be detected and cannot be completely eliminated among hrHPV other than 16\/18\u2010infected women with negative cytology. Based on the results of this study, referral of non\u201016\/18 hrHPV\u2010infected women with negative cytology to colposcopy is supported as a credible and feasible strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24705","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T03:18:52Z","timestamp":1612581532000},"page":"480-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The meaning of high\u2010risk <scp>HPV<\/scp> other than type 16\/18 in women with negative cytology: Is it really safe to wait for 1 year?"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-279X","authenticated-orcid":false,"given":"Canan","family":"Kabaca","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Zeynep Kamil Training and Research Hospital University of Health Sciences  Istanbul 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