{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:52:39Z","timestamp":1747147959369,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Olfactory neuroblastoma (ONB) is a rare malignant neuroectodermal tumor. Due to the rarity, there are scarce reports describing the cytological features of ONB. Thus, we aimed to analyze these cytological features and discuss their differences depending on the histological grading of ONB. Patients with a histopathological diagnosis of ONB who underwent fine\u2010needle aspiration cytology were enrolled in the study. The cytological features, including arrangement and shape of neoplastic cells, nuclear features, and presence of rosettes, were analyzed. Eight patients with ONB were enrolled; cytological specimens of seven patients were obtained from metastatic lesions and that of one patient were obtained from the nasal cavity tumor. The cytological specimens demonstrated variable\u2010sized clusters of neoplastic cells and single cells. Two\u2010cell pattern, composed of large\u2010sized viable neoplastic cells and small\u2010sized apoptotic cells, was noted in 3 of 4 high\u2010grade ONBs but in none of 4 low\u2010grade ONBs. This reflects that the presence of the two\u2010cell pattern may represent higher proliferation in neoplastic cells. The neoplastic cells had scant cytoplasm and round to oval nuclei containing fine to granular chromatin without conspicuous nucleoli. Rosettes and paranuclear blue bodies were observed in one patient. Most cytological specimens of ONB were obtained from metastatic lesions, especially from the cervical lymph node. Thus, ONB should be differentiated from malignant lymphoma and small cell neuroendocrine carcinoma. Recognition of these cytological features of ONB while considering patient history can aid in correctly diagnosing ONBs. Moreover, the presence of two\u2010cell pattern might reflect high\u2010grade histology of ONB.<\/jats:p>","DOI":"10.1002\/dc.24728","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T12:37:11Z","timestamp":1614256631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Review of the cytological features of olfactory neuroblastoma: A retrospective single\u2010center study"],"prefix":"10.1002","volume":"49","author":[{"given":"Kimiaki","family":"Okano","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-4118","authenticated-orcid":false,"given":"Mitsuaki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Sandoh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tsuta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kansai Medical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"volume-title":"WHO Classification of Head and Neck Tumours","year":"2017","author":"El\u2010Naggar AK","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22373"},{"volume-title":"Olfactory Neuroblastoma. In: Tumors of the Upper Respiratory Tract and Ear. Atlas of Tumor Pathology","year":"1988","author":"Hyams VJ","key":"e_1_2_8_4_1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/C00WN1HHJ9AMBJVT"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21718"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332707"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326714"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199709)17:3<205::AID-DC7>3.0.CO;2-D"},{"key":"e_1_2_8_10_1","first-page":"86","article-title":"Diagnosis of olfactory neuroblastoma by cytology","volume":"88","author":"Prasad N","year":"1990","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_8_11_1","first-page":"381","article-title":"Olfactory neuroblastoma. Cytodiagnostic features in a case with ultrastructural and immunohistochemical correlation","volume":"32","author":"Ferris CA","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_8_12_1","first-page":"377","article-title":"Cytologic appearance of esthesioneuroblastoma in a fine needle aspirate","volume":"32","author":"Jele\u0144 M","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840010411"},{"key":"e_1_2_8_14_1","first-page":"299","article-title":"Cytologic diagnosis of olfactory neuroblastoma. Report of a case with multiple diagnostic parameters","volume":"27","author":"Jobst SB","year":"1983","journal-title":"Acta Cytol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840100304"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191244"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T14:35:43Z","timestamp":1693406143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/dc.24728"],"URL":"https:\/\/doi.org\/10.1002\/dc.24728","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2021,2,25]]},"assertion":[{"value":"2020-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}