{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:52:40Z","timestamp":1747147960138,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost\u2010effective for solid tumor diagnosis. This study aims to evaluate the role of FNAC in the diagnosis of various infantile solid tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, 61 cases of FNA of infant solid tumors were retrieved from the cytology archives over a period of 5\u2009years from January 2013 to December 2017. Cytomorphology was studied and immunohistochemistry on cell block was performed wherever feasible. Histopathological correlation was done in 19 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 61 cases studied, 60 cases were included in the study of which 35 were male and 25 were female. Infantile solid tumors constituted 7.3% of all pediatric solid tumors reported in cytopathology division of our Institute. The most common final diagnosis was NB (15, 25%) followed by HBL (13, 21.6%), WT (10, 16.6%), RMS (nine, 15%) and GCT (nine, 15%). The commonest site was abdominal\u2010pelvic (42, 70%). A definitive independent diagnosis could be made on FNA in 48 cases (80%). Follow\u2010up was done for 1.5 to 4\u2009years (mean 26 months). The highest and lowest mortality was noted in NB (64.3%) and WT (12.5%) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study concludes that FNAC can be adopted as a diagnostic modality in infant solid tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24735","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T15:08:49Z","timestamp":1615475329000},"page":"743-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis of solid tumors in infants by fine\u2010needle aspiration cytology: 5\u2009years retrospective study from a tertiary care oncology center in South India"],"prefix":"10.1002","volume":"49","author":[{"given":"Malathi","family":"Mukundapai","sequence":"first","affiliation":[{"name":"Cytology Division Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Cytology Division Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-1086","authenticated-orcid":false,"given":"Ashwini","family":"Nargund","sequence":"additional","affiliation":[{"name":"Cytology Division Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta V.","family":"Patil Okaly","sequence":"additional","affiliation":[{"name":"Histopathology Division Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. L.","family":"Kavitha","sequence":"additional","affiliation":[{"name":"Cytogenetics Division, Department of Pathology Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Padma","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Madhu","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Kidwai Memorial Institute of Oncology  Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2017-0057"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"5","article-title":"An audit of malignant solid tumors in infants and neonates","volume":"1","author":"Bhatnagar SN","year":"2012","journal-title":"J Neonatal Surg"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/61.3.263"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.7.616-a"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005480"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.12.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2013.852644"},{"issue":"9","key":"e_1_2_10_9_1","first-page":"2215","article-title":"Childhood cancer incidence and survival 2003\u20102005, Thailand: study from the Thai pediatric oncology group","volume":"12","author":"Wiangnon S","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950040304"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-53441-0_2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23085"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850415)55:8<1805::AID-CNCR2820550828>3.0.CO;2-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.5.653"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816631728"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics8020028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.44038"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90126-4"},{"issue":"1","key":"e_1_2_10_19_1","first-page":"90","article-title":"Fine\u2010needle aspiration biopsy in the diagnosis of pediatric tumors","volume":"154","author":"Layfield LJ","year":"1991","journal-title":"West J Med"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199908)21:2<81::AID-DC2>3.0.CO;2-A"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-018-1229-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100533"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100137867"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.1.101"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0463-RA"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0138-z"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:27:32Z","timestamp":1693546052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/dc.24735"],"URL":"https:\/\/doi.org\/10.1002\/dc.24735","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"assertion":[{"value":"2020-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}