{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:42:01Z","timestamp":1781149321422,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant melanoma is a well\u2010known diagnostic pitfall, given its propensity to metastasize to different sites and mimic various entities. In this report, we present a fine\u2010needle aspiration biopsy (FNA) of a metastatic melanoma with basaloid features that is occurring in the preauricular\/parotid area. The patient is a 17\u2010year\u2010old male with a history of excision of melanoma of the left temple, and was undergoing adjuvant treatment with nivolumab. The prior excision was positive for S100, HMB\u201045, melan\u2010A, and tyrosinase. On follow\u2010up, he presented with non\u2010FDG avid left preauricular area lesions. FNA was performed, and on\u2010site evaluation demonstrated a cellular basaloid neoplasm with focal fibrillary stroma. Immunohistochemical stains revealed that the tumor cells were positive for SOX\u201010, S100, MITF, and HMGA2, and were negative for HMB\u201045, melan\u2010A, tyrosinase, p63, cam 5.2 and PLAG1. The positive S100, SOX\u201010, and MITF results and negative cam 5.2 result supported the diagnosis of melanoma. Nivolumab was then stopped, Dabrafenib\/Trametinib were started, and the patient underwent excision of the nodules. Nine\u2010months later, he developed a rib metastasis that was positive for S100, SOX\u201010, melan\u2010A, and tyrosinase. This report emphasizes that melanoma involving the parotid gland region has the potential to be misdiagnosed by FNA as a salivary gland neoplasm because of overlapping cytologic features and immunophenotypes. This pitfall is avoided by careful morphologic analysis and judicious use of ancillary studies.<\/jats:p>","DOI":"10.1002\/dc.24817","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T12:41:10Z","timestamp":1624711270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-532X","authenticated-orcid":false,"given":"Sigfred","family":"Lajara","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2871-5409","authenticated-orcid":false,"given":"Michael","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.3.5.569"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3010126"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354405"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2014.14.4.279"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0552-OA"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0327-RA"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24376"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2034"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13246"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.197"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12504"},{"issue":"1","key":"e_1_2_5_13_1","first-page":"77","article-title":"Malignant melanoma of unknown primary site simulating a salivary gland neoplasm","volume":"27","author":"Agarwal K","year":"2011","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000619"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:02:13Z","timestamp":1692817333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/dc.24817"],"URL":"https:\/\/doi.org\/10.1002\/dc.24817","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"2021-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}