{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T22:15:30Z","timestamp":1716934530811},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The existence of baseline data on the spectrum of thyroid nodules in Bhutanese patients is unknown. Fine\u2010needle aspiration cytology (FNAC) is regarded as the gold standard diagnostic test for pre\u2010op assessment of thyroid lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted a retrospective study, involving 765 patients who underwent FNAC of the thyroid gland, at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, between January\u20102018 to December\u20102020. We aimed to assess the cytomorphological spectrum of thyroid nodules, classify them as per The Bethesda system for reporting thyroid cytopathology (TBSRTC), assess risk of malignancy (ROM), and evaluate the accuracy of FNAC in diagnosing thyroid malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Colloid nodule (37.4%) and papillary thyroid carcinoma (4.2%) constituted the majority of benign and malignant cytological diagnoses, respectively. According to TBSRTC, majority of the cases (82.0%) fell under the Bethesda II category. Bethesda III was the least common (1.4%) category. As compared to histopathological diagnosis; the sensitivity, specificity, positive and the negative predictive values of FNAC in diagnosing thyroid malignancy were 90.0%, 93.3%, 93.10%, and 90.32% respectively. The ROM increased concurrently with the grade of the Bethesda category and was more or less close to the ROM reference range, published in the TBSRTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Benign thyroid nodules (82.0%) constituted a majority of thyroid nodules in Bhutanese patients. FNAC was found to be reliable in detecting thyroid malignancy. From the literature, TBSRTC was found to be a more convenient method for reporting thyroid cytology. Henceforth, as most institutes, we plan to implement TBSRTC for reporting thyroid cytopathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24843","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T16:16:26Z","timestamp":1627488986000},"page":"1179-1187","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of the Bethesda system for reporting thyroid cytopathology for classification of thyroid nodules: A clinical and cytopathological characteristics in Bhutanese population"],"prefix":"10.1002","volume":"49","author":[{"given":"Sonam","family":"Choden","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Jigme Dorji Wangchuck National Referral Hospital  Thimphu Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chimi","family":"Wangmo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Central Regional Referral Hospital  Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushna","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Jigme Dorji Wangchuck National Referral Hospital  Thimphu Bhutan"},{"name":"Department of Pathology Chitwan Medical College Teaching Hospital  Chitwan Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2017.08.12"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.019"},{"issue":"7","key":"e_1_2_10_4_1","first-page":"783","article-title":"Evaluation of thyroid fine needle aspiration cytology by the Bethesda Reporting System: a retrospective analysis of rates and outcomes from the King Chulalongkorn Memorial Hospital","volume":"100","author":"Limlunjakorn P","year":"2017","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_10_5_1","volume-title":"WHO Classification of Tumors of Endocrine Organs","author":"Lloyd RV","year":"2017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2020.1024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"142","article-title":"Fine needle aspiration cytological study of various thyroid lesions and its clinical correlation in a tertiary health care centre\u2014a prospective study","volume":"4","author":"Dharrao SS","year":"2017","journal-title":"MPV J Med Sci"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20830"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0274"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"issue":"6","key":"e_1_2_10_13_1","first-page":"5","article-title":"Study of spectrum of thyroid lesion on FNAC at tertiary care center","volume":"5","author":"Bhagwat MK","year":"2019","journal-title":"Int J Med Health Res"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/379051"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20175728"},{"issue":"6","key":"e_1_2_10_16_1","first-page":"517","article-title":"A study of malignancy rates in different diagnostic categories of the Bethesda system for reporting thyroid cytopathology: an institutional experience","volume":"38","author":"Arul P","year":"2015","journal-title":"Biom J"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.112650"},{"key":"e_1_2_10_18_1","first-page":"62","volume-title":"A Practical Guide to the Correction of Iodine Deficiency","author":"Dunn JT","year":"1990"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/9780470370124.ch12","volume-title":"Iodine and Human Health: Bhutan's Iodine Fortification Program. 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