{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:42:53Z","timestamp":1761766973104,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The coronavirus COVID\u201019 pandemic has spurred the rapid development of vaccines, with vaccination programmes already underway in many countries. Regional lymphadenopathy is one of the documented side effects of vaccination. We document the fine needle aspiration cytological findings of an enlarged supraclavicular lymph node in a 34\u2010year\u2010old Asian female following the first dose of the Pfizer\u2010BioNTech COVID\u201019 mRNA vaccine, which appears to be the first such report in a premorbidly well patient with no known history of malignancy. The cytological findings featured a reactive pattern in keeping with follicular hyperplasia, with prominent germinal centre elements including lymphohistiocytic aggregates and tingible\u2010body macrophages. Despite an increased proportion of larger lymphocytes, the overall pattern was in keeping with a reactive pattern, bearing in mind the temporal and geographic relation to the vaccination injection. In instances of localised lymphadenopathy, particularly in supraclavicular or axillary locations, pathologists should be cognizant of the possibility of post\u2010vaccination reactive lymphadenopathy, and seek clinical and radiological hints favouring a benign process, whilst recognising potential morphological overlaps with lymphoproliferative disorders. Awareness of this diagnostic pitfall is especially important as COVID\u201019 vaccination coverage is ramped up worldwide, leading to an expected increase in incidence of post\u2010vaccination reactive lymphadenopathy.<\/jats:p>","DOI":"10.1002\/dc.24863","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T12:56:33Z","timestamp":1629896193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>COVID<\/scp>\u201019 post\u2010vaccination lymphadenopathy: Report of cytological findings from fine needle aspiration biopsy"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-3233","authenticated-orcid":false,"given":"Nicholas Jin Hong","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology National University Hospital, National University Health System  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Xun Joshua","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery (ENT) National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Boon Justin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Hospital, National University Health System  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min En","family":"Nga","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Hospital, National University Health System  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Pfizer Inc.Pfizer\u2010BioNTech COVID\u201019 Vaccine EUA Fact Sheet for Recipients and Caregivers [Internet]. FDA;2021https:\/\/www.fda.gov\/media\/144414\/download."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.9.1194"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196804)21:4<632::AID-CNCR2820210415>3.0.CO;2-O"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021210275"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003597"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.25604"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2021.01.016"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.10.2100193"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2021.04.007"},{"issue":"2","key":"e_1_2_5_11_1","article-title":"Lymphadenopathy associated with the COVID\u201019 vaccine","volume":"13","author":"Hiller N","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2021.04.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.25683"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.2021210038"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2021.03.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9010061"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.08.006"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.05.031"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24863","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:20:47Z","timestamp":1693200047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/dc.24863"],"URL":"https:\/\/doi.org\/10.1002\/dc.24863","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"2021-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}