{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:09:19Z","timestamp":1788566959713,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402320"],"award-info":[{"award-number":["81402320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["16JCYBJC27000"],"award-info":[{"award-number":["16JCYBJC27000"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010grade serous carcinoma (HGSC) is the most common epithelial carcinoma of the tubo\u2010ovarian region, with a poor prognosis, which presents with an advanced stage at the time of diagnosis. This study summarizes the cytological features of cervical liquid\u2010based cytological examination in order to diagnose ovarian or tubal HGSC at an early stage by cervical cytology smear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 12 patients who were diagnosed with atypical glandular cell (AGC) and above lesions by cervical cytological examination and ovarian or tubal HGSC by histopathology were enrolled in this study. The cytological characteristics, including the arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and the presence of tumor diathesis were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine cases were determined to be AGC, and three cases were determined to be AGC favor neoplastic (AGC\u2010FN) in the 12 cervical cytological diagnoses. The glandular cells showed significant atypia and proliferated actively with a three\u2010dimensional structure. Increased nuclear\u2010to\u2010cytoplasmic ratios, prominent nucleoli, and hyperchromasia were common. Vacuole\u2010like changes were observed in the cytoplasm. Tumor diathesis was observed in only one case (1\/12, 8.30%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ovarian or tubal HGSC can occasionally be detected using cervical liquid\u2010based cytology. It has distinct cytological characteristics. Primary ovarian or tubal HGSC with positive cervical cytology was accompanied by tumor cells in ascites, which suggested that the patient had progressed to an advanced stage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24871","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T14:01:49Z","timestamp":1631282509000},"page":"1207-1212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cytological features of ovarian or tubal high\u2010grade serous carcinoma: A retrospective study of 12 cases with abnormal cervical liquid\u2010based smear"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5181-5133","authenticated-orcid":false,"given":"Yanning","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and Reproductive Regulation  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and Reproductive Regulation  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and Reproductive Regulation  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and Reproductive Regulation  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23452"},{"key":"e_1_2_7_3_1","first-page":"249","article-title":"Atypical glandular cells of undetermined significance. 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