{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:27:26Z","timestamp":1783636046246,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persistent infection with high\u2010risk human papillomavirus (HR\u2010HPV) is the main leading cause of cervical precancerous lesions and cervical cancer. This study aims to explore the epidemiological characteristics of HR\u2010HPV genotypes and their correlation with the ThinPrep cytological test (TCT) results among women in Chongqing, in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, cervical exfoliations of 14,548 women who visited Chongqing university cancer hospital were collected for detecting HR\u2010HPV genotypes and TCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the rate of HR\u2010HPV infection was 14.26%. The three most common HR\u2010HPV genotypes are HPV52 (4.39%), HPV58 (2.21%), and HPV16 (1.94%). In this study, the positive rate of cervical TCT was 4.54%. Atypical squamous cells of undetermined significance (ASC\u2010US), atypical squamous cells that could not exclude high\u2010grade squamous intraepithelial lesion (ASU\u2010H), low\u2010grade squamous intraepithelial lesions (LSIL), high\u2010grade squamous intraepithelial lesions (HSIL), and atypical glandular cells of undetermined significance (AGC) were 2.99%, 0.20%, 0.92%, 0.29%, and 0.14%, respectively. Among the several types of cytological lesions, the HR\u2010HPV infection rates of ASC\u2010US, ASC\u2010H, LSIL, HSIL, and (AGC) were 24.82%, 41.38%, 64.18%, 95.24%, and 23.81%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HPV52, HPV 58, and HPV16 are the most common infection subtypes in Chongqing. When implementing HPV vaccine programs in Chongqing, HPV58 and HPV52 should be attached importance as HPV16 and HPV18.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24891","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T09:04:54Z","timestamp":1635411894000},"page":"1237-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and genotype distribution of high\u2010risk human papillomavirus infection among women with cervical cytological abnormalities in Chongqing, China, 2014\u20132020"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-2629","authenticated-orcid":false,"given":"Qinli","family":"Luo","sequence":"first","affiliation":[{"name":"Health Examination and Oncology Screening Center Chongqing University Cancer Hospital &amp; Chongqing Cancer Institute &amp; Chongqing Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lang","sequence":"additional","affiliation":[{"name":"Health Examination and Oncology Screening Center Chongqing University Cancer Hospital &amp; 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