{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:41:47Z","timestamp":1785404507979,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["Junior Clinical Investigator Award (C.C.J.)"],"award-info":[{"award-number":["Junior Clinical Investigator Award (C.C.J.)"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Descriptions of parathyroid cell cyto\u2010morphology are limited. Fine\u2010needle aspiration cytology (FNAC) with immunocytochemistry (ICC) or biochemical PTH measurements may help verify the parathyroid origin in extraordinary cases, although these methods are nowadays largely replaced by imaging techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected all available FNAC reports of parathyroid lesions from our department spanning 20\u2009years, to characterize the clinical use of parathyroid FNAC, and to assess morphological correlates between cytology and subsequent histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight cases with assessable cytological smears were found, of which 21 cases were surgically resected and 20 available for histological review (15 adenomas, 2 carcinomas, 2 atypical tumors and a single case with secondary hyperplasia). FNAC was predominantly performed to localize the diseased gland in cases with inconclusive imaging, in cases with a suspicion of intrathyroidal localization or in cases with persistent hypercalcemia following unsuccessful surgery. The diagnosis was verified using either PTH ICC and\/or PTH measurements for most cases, and the procedure affected the clinical decision\u2010making for the majority of patients in this selected cohort. Cytological differences between parathyroid adenomas and carcinomas were found, as only carcinomas showed pleomorphism with irregular nuclei and prominent nucleoli. Morphologically, no correlations to predominant cell types or growth patterns visualized at histological investigations among adenomas were noted, and biopsy artifacts were evident in 40% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parathyroid FNAC could be considered as a complementary analysis for a small group of selected patients, but benefits have to be weighed against the risk of biopsy artifacts in histological preparations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24923","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T07:41:31Z","timestamp":1640677291000},"page":"75-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cyto\u2010morphological features of parathyroid lesions: Fine\u2010needle aspiration cytology series from an endocrine tumor referral center"],"prefix":"10.1002","volume":"50","author":[{"given":"Sanna","family":"Steen","sequence":"first","affiliation":[{"name":"Department of Pathology and Cytology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hysek","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Zedenius","sequence":"additional","affiliation":[{"name":"Department of Breast, Endocrine Tumors and Sarcoma Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Falhammar","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Endocrinology, Metabolism and Diabetes Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-9081","authenticated-orcid":false,"given":"Carl Christofer","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31430-7"},{"key":"e_1_2_8_3_1","article-title":"Major clues and pitfalls in the differential diagnosis of parathyroid and thyroid lesions using fine needle aspiration cytology","volume":"56","author":"Ha HJ","year":"2020","journal-title":"Med Kaunas Lith"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21203"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21888"},{"key":"e_1_2_8_6_1","first-page":"852","article-title":"Institutional characterisation of water clear cell parathyroid adenoma: a rare entity often unrecognised by TC\u201099m\u2010sestamibi scintigraphy","volume":"53","author":"Juhlin CC","year":"2021","journal-title":"Pathology (Phila)"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23711"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20115"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-3-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2013.47.5.466"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.175490"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23528"},{"key":"e_1_2_8_15_1","volume-title":"Orell and Sterrett's Fine Needle Aspiration Cytology","author":"Orell SR","year":"2021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24338"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-020-09656-9"},{"key":"e_1_2_8_18_1","first-page":"355","volume-title":"International Agency for Research on Cancer, Editors. WHO Classification of Tumours of Endocrine Organs. 4th Edition","author":"Lloyd RV","year":"2017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0081"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24923","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:30:55Z","timestamp":1693222255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,27]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/dc.24923"],"URL":"https:\/\/doi.org\/10.1002\/dc.24923","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,27]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}