{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:02:37Z","timestamp":1772629357955,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytokeratin 19 (CK19) is low\u2010molecular weight CK with widespread expression in various malignancies including those of lung, colon, and breast. Occasional studies have also indicated prognostic utility of CK19 in nonsmall cell lung carcinomas, with better prognosis among squamous cell carcinoma cases with strong CK19 immunostaining. The aim of this study was to evaluate the expression and potential roles of CK19 immunostaining in cases of carcinoma lung as well as other metastatic intrathoracic neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective single\u2010center study of 2\u2009years duration, during which 233 cases of endobronchial ultrasound guided aspiration of the intrathoracic lesions were examined. After excluding the cases without cellblock, with inadequate samples, with benign diagnosis, and excluding the lymphoma cases, finally 31 neoplastic cases were evaluated for expression of cytokeratin 19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diffuse cytoplasmic staining for CK19 was noted in nonsmall cell lung carcinomas (18\/19 cases), while the expression in small cell carcinomas was low (2\/5 cases). CK19 was also positive in mediastinal lymph node metastasis from a case each of papillary thyroid carcinoma, prostatic adenocarcinoma and infiltrating ductal carcinoma breast (1\/2 cases). It showed focal faint staining in a case of mediastinal mesenchymal neoplasm and was negative in both the cases of primitive neuroectodermal tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CK19 is a highly sensitive but nonspecific marker for nonsmall cell lung cancers. However, owing to diffuse staining pattern in most of these cases, role of its staining intensity as a predictor of prognosis could not be evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24927","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:00:06Z","timestamp":1641290406000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cytokeratin 19 expression in intrathoracic neoplasms: First study utilizing cellblocks, evaluating the role of a rarely used cytokeratin for lung cancers"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-8503","authenticated-orcid":false,"given":"Vikrant","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Pathology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-5138","authenticated-orcid":false,"given":"Ram Nawal","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01387.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28768"},{"key":"e_1_2_9_4_1","first-page":"51","article-title":"Cytokeratin 19 (CK19) as a marker for epithelial differentiation and malignant transformation: its clinical relevance in diagnosis, prognosis and treatment response monitoring","volume":"2","author":"Mujyambere B","year":"2018","journal-title":"IRE J"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.52.35176"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.09.018"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"317","article-title":"The prognostic value of cytokeratin 19 expression in non\u2010small cell lung cancer","volume":"75","author":"Kosacka M","year":"2007","journal-title":"Pneumonol Alergol pol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.101167"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/JOC.JOC_55_21"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"162","article-title":"Immunohistochemical analysis of tissue localization of cytokeratin 19 in lung cancer","volume":"42","author":"Chyczewski L","year":"1997","journal-title":"Rocz Akad Med Bialymst"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"54","article-title":"Immunohistochemical expression of Cytokeratin\u201019 in non small cell lung carcinomas \u2010 an experience from a tertiary Care Hospital in Lahore. International","volume":"8","author":"Naseem N","year":"2010","journal-title":"J Pathol"},{"issue":"11","key":"e_1_2_9_12_1","first-page":"3221","article-title":"Cytokeratins in different types of human lung cancer as monitored by chain\u2010specific monoclonal antibodies","volume":"48","author":"Broers JL","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5010001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.99746"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2011.12.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60781-8"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:38:57Z","timestamp":1693111137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/dc.24927"],"URL":"https:\/\/doi.org\/10.1002\/dc.24927","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"2021-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}