{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:53:14Z","timestamp":1747147994674,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant granular cell tumors (GCTs) account for less than 2% of all GCTs and mainly occur in the deep soft tissue of the thigh or trunk. Malignant GCTs are highly aggressive tumors with high rates of recurrence and metastasis. In this brief report, we describe a rare case of malignant GCT in a 64\u2010year\u2010old Japanese man who presented with a 14\u2009\u00d7\u200920\u2009cm mass in the left inguinal region. The cytologic findings of fine\u2010needle aspiration (FNA) revealed atypical epithelial\u2010like granular cells with granular substance in the background, which was difficult to differentiate from apocrine carcinoma or melanoma. The immunohistochemistry (IHC) findings of the needle biopsy revealed that the tumor cells were positive for S\u2010100 and lysosomal marker CD68 which was suggestive of a GCT. However, the presence of crush artifacts made it challenging to identify cellular atypia, which is a characteristic of malignant tumor. Taken together, the FNA and needle biopsy results were suggestive of malignant GCT. The importance of preoperative diagnosis of malignant GCT is well known, but few reports have described its cytological findings. In our brief report, we show that combining cytological FNA and biopsy findings with IHC findings achieves an accurate diagnosis of malignant GCT.<\/jats:p>","DOI":"10.1002\/dc.24970","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T11:24:18Z","timestamp":1650972258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis"],"prefix":"10.1002","volume":"50","author":[{"given":"Atsumi","family":"Enomoto","sequence":"first","affiliation":[{"name":"Division of Pathology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-8279","authenticated-orcid":false,"given":"Mika","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology Nippon Medical 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