{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:53:08Z","timestamp":1774381988918,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Core needle biopsy (CNB) and fine needle aspiration (FNA) are currently the most common biopsy methods for investigation of soft tissue lesions. Selection of the method to be used depends on a number of factors including diagnostic accuracy, local expertise with the techniques and the need for ancillary testing. We investigated the diagnostic accuracy of CNB and factors influencing the selection of CNB or FNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic search of the surgical pathology records for all core needle biopsies of soft tissue lesions with subsequent incisional biopsies or excisions between January 1, 2015 and December 31, 2021 was performed. Searches of the literature for publications documenting diagnostic accuracy of core biopsy and FNA were performed using the Pub Med literature data base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The electronic search yielded 177 CNBs with appropriate follow\u2010up. Six cases were non\u2010diagnostic. The remaining 171 cases showed an accuracy of 90% for separation of benign from malignant with two false\u2010positive and 17 false\u2010negative diagnoses. The literature search revealed 11 series of CNBs with a diagnostic accuracy of 74% to 97%. The literature search revealed 20 series of FNAs with an accuracy of 84.8% to 100% for separation of benign from malignant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Core needle biopsy is a highly accurate diagnostic technique with an accuracy of 90% for separation of benign from malignant lesions. The percentage of non\u2010diagnostic cases is low (3.4%). No significant biopsy related complications were seen in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.25012","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T06:09:28Z","timestamp":1657087768000},"page":"442-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Core needle biopsy for the diagnosis of primary soft tissue lesions: Accuracy and diagnostic challenges"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-6506","authenticated-orcid":false,"given":"Lester J.","family":"Layfield","sequence":"first","affiliation":[{"name":"Department of Pathology and Anatomical Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Stegelmeier","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomical Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomical Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-9603","authenticated-orcid":false,"given":"Magda","family":"Esebua","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomical Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198264080-00002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1724\u20106413\u20104\u201020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000625)90:3<178::AID-CNCR6>3.0.CO;2-S"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.5.632"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32735"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.06.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24355"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12914"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0474-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.73B3.1670457"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199605000-00002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.3.r99se19682"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.3.275"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03332.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00430-1"},{"key":"e_1_2_9_18_1","first-page":"165","article-title":"Value of core needle biopsy in the diagnosis of soft tissue tumours","volume":"45","author":"Madhavan VP","year":"2002","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-005-0038-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-009-0835-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPBWJP3CG6JZKA"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1401-x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21172"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1100-7"},{"issue":"1","key":"e_1_2_9_25_1","first-page":"131","article-title":"Fine\u2010needle aspiration (FNA) in soft tumours (STT)","volume":"22","author":"Klijanienko J","year":"2011","journal-title":"Cytopathology"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.97154"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.09.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.130629"},{"key":"e_1_2_9_29_1","first-page":"1127","article-title":"Accuracy of fine needle aspiration cytology in the diagnosis of bone lesions with radiological assistance: experience from the National Cancer Institute. 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