{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:34:36Z","timestamp":1777901676834,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To investigate the clinical value of the ThinPrep cytologic test (TCT) with the E6\/E7 mRNA test for cervical cancer screening in disease diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 405 samples from Dazhou Central Hospital from April 2017 to July 2020 were collected, and we conducted a comparative analysis of the diagnostic performance of several test methods both individually andcombination.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve (AUC) were compared by single TCT, E6\/E7 mRNA test, and combination methods. The TCT+E6\/E7mRNA test was confirmed to have a relatively higher specificity of 80.32% (95% CI: 75.40%\u201384.48%, both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and AUC value (0.78, 95% CI: 0.73\u20130.83, and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The relative diagnostic value may be further improved by the combined detection of TCT and E6\/E7 mRNA test. The combined detection of TCT and the E6\/E7 mRNA test is expected to become a potential indicator for cervical lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.25025","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T09:25:05Z","timestamp":1659345905000},"page":"513-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical value of the ThinPrep cytologic test with E6\/E7 mRNA detection for cervical cancer screening in disease diagnosis"],"prefix":"10.1002","volume":"50","author":[{"given":"Liyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gynecology Dazhou Central Hospital  Dazhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gynecology Dazhou Central Hospital  Dazhou People's Republic of 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