{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:23:24Z","timestamp":1756463004915,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dasatinib, a second\u2010generation tyrosine kinase inhibitor (TKI), used as treatment for chronic myeloid leukemia, <jats:italic>BCR::ABL1<\/jats:italic>\u2010positive (CML), is complicated by pleural or pericardial effusions in about one\u2010third of patients. Besides, in exceptional instances, effusion\u2010based neoplastic B\u2010cell lymphoproliferations have been described. Here, we report an HHV8\u2010negative, EBV\u2010positive large B\u2010cell lymphoma presenting as a pericardial effusion in a patient with CML treated with dasatinib for 23\u00a0months, without associated tumor mass or lymphadenopathies. Large tumor cells showed a B\u2010cell phenotype (CD20+, CD79+), with evidence of EBV infection (EBER\u2010ISH+), but HHV8 (LANA\u20101) negative. Monoclonal IG gene rearrangements were identified. <jats:italic>BCL2, BCL6<\/jats:italic>, and <jats:italic>MYC<\/jats:italic> genes were not rearranged. Despite the aggressive cytomorphology the patient was in complete remission after 4\u00a0cycles of R\u2010CHOP after 8\u2009months follow\u2010up. Four other cases of large B\u2010cell effusion\u2010based lymphomas developed in the setting of dasatinib therapy for CML have been reported in the literature. The four cases were HHV8\u2010negative and one case was EBV\u2010positive. Three of the four patients experienced a benign clinical course, which is in contrast to HHV8\u2010positive primary effusion lymphoma (PEL). The mechanisms of development of these effusion\u2010based B\u2010cell lymphoproliferations in patients receiving TKI are not completely elucidated. Acute or relapsing effusions during TKI treatment in the setting of CML should be cytologically examined to exclude clonal B\u2010cell lymphoproliferations.<\/jats:p>","DOI":"10.1002\/dc.25027","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T16:03:06Z","timestamp":1659456186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["HHV8\u2010negative primary effusion\u2010based large B\u2010cell lymphoma in a patient with chronic myeloid leukemia, <i>BCR::ABL1<\/i>\u2010positive under dasatinib treatment: Report of a new case and literature review"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8847-9391","authenticated-orcid":false,"given":"Lucine","family":"Christe","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Institute of Pathology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Veloza","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Institute of Pathology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Gros","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Bisig","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Institute of Pathology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Blum","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekkehard","family":"Hewer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Institute of Pathology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Institute of Pathology University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017","author":"Swerdlow 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