{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:33:43Z","timestamp":1790829223350,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spindle cell\/sclerosing rhabdomyosarcoma (RMS), characterized by <jats:italic>MYOD1 (L122R)<\/jats:italic> mutation in a subset of cases is a newly described subtype of RMS. Presently, there is no documentation of cytomorphological features, especially of sclerosing RMS. Case 1: A 24\u2010year\u2010old male presented with pain and swelling in his wrist for a one\u2010year duration. MRI revealed a well\u2010defined soft tissue lesion measuring 5.3\u00a0cm, encasing the lower end of the ulna. Fine\u2010needle aspiration cytology (FNAC) smears revealed clusters of tumor cells with round to oval to spindle\u2010shaped nuclei, scant to moderate amount of cytoplasm with the wisps of the metachromatic stroma. Histopathological examination revealed a malignant tumor comprising cells with polygonal to spindle\u2010shaped nuclei, arranged in a sclerotic stroma. Immunohistochemically, the tumor cells were positive for desmin, myogenin, and <jats:italic>MYOD1<\/jats:italic>. A diagnosis of sclerosing RMS was offered. Furthermore, the tumor revealed <jats:italic>MYOD1 (L122R)<\/jats:italic> mutation. Case 2: A 43\u2010year\u2010old male presented with a 4\u2010month history of \u201cnasal stuffiness\u201d and pressure. Imaging revealed a poorly defined infiltrative lesion in his nasal cavity. FNAC smears revealed loose and tightly cohesive clusters of malignant cells with oval to spindle\u2010shaped nuclei, a moderate amount of ill\u2010defined bluish to finely vacuolated cytoplasm, and focal streak artifact with interspersed stromal fragments. Histopathological examination revealed a malignant tumor composed of oval to spindle\u2010shaped nuclei, embedded in a variably hyalinized stroma. Immunohistochemically, the tumor cells were positive for desmin, and myogenin. Diagnosis of spindle cell\/sclerosing RMS was offered. The present study constitutes one of the first documentation of cytomorphological features of two rare cases of spindle cell\/sclerosing RMS. The differential diagnoses and treatment\u2010related implications are presented.<\/jats:p>","DOI":"10.1002\/dc.25032","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T13:19:18Z","timestamp":1659705558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytomorphology of spindle cell\/sclerosing rhabdomyosarcoma, including <i><scp>MYOD1<\/scp> (<scp>LI22R<\/scp>)<\/i> mutation result"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-4794","authenticated-orcid":false,"given":"Bharat","family":"Rekhi","sequence":"first","affiliation":[{"name":"Department of Pathology Tata Memorial Hospital  Mumbai India"},{"name":"Homi Bhabha National Institute (HBNI) University  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Dodd","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Dharavath","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute (HBNI) University  Mumbai India"},{"name":"Integrated Genmomics Laboratory Advanced Centtre for Treatment, Research and Education in Cancer  Khargar, Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-4774","authenticated-orcid":false,"given":"Amit","family":"Dutt","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute (HBNI) University  Mumbai India"},{"name":"Integrated Genmomics Laboratory Advanced Centtre for Treatment, Research and Education in Cancer  Khargar, Navi Mumbai 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