{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:53:24Z","timestamp":1747148004598,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Langerhans cell histiocytosis (<jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>) is a disease of unknown etiology characterized by a proliferation of histiocytic cells resembling dendritic Langerhans cells.<jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>can be unifocal or multifocal, with one\u2010 or many\u2010organ involvement. The serous fluids are rarely involved. Cytological diagnosis of<jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>is possible and relies on recognition of the typical cytomorphological features and subsequent immunocytochemical confirmation. Given the possibility of multisystem involvement, after diagnosing<jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>it is necessary to carry out staging exams such as a bone survey, abdominal ultrasound, complete blood count, screening for diabetes insipidus and pulmonary function tests. We present the first case of<jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>where the diagnosis was reached on cytological material from the cerebrospinal fluid. To the best of our knowledge, this is the first such case reported in the international literature to date. The morphological and immunocytochemical characteristics of our case are described, and the relevant literature is reviewed<\/jats:p>","DOI":"10.1002\/dc.25040","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T11:10:42Z","timestamp":1660216242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosis of Langerhans cell histiocytosis on cytological examination of cerebrospinal fluid: Report of the first case"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-1803","authenticated-orcid":false,"given":"Francesco","family":"Tommasino","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-3993","authenticated-orcid":false,"given":"Chiara","family":"Cardamone","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Tortora","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sabbatino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Di Sarno","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Naples \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-3869","authenticated-orcid":false,"given":"Alessandro","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"},{"name":"Department of Medicine University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(05)75054-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.06.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333916"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468505"},{"volume-title":"StatPearls","year":"2021","author":"Tillotson 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now","volume":"64","author":"Caputo A","year":"2021","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101916"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12709"}],"container-title":["Diagnostic 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