{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:51:13Z","timestamp":1747147873599,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Signet\u2010ring cells are morphologically defined by the presence of a large intracytoplasmic vacuole that compresses and displaces the nucleus to the periphery. In most cases, these cells are associated with adenocarcinomas of various locations, and with non\u2010epithelial neoplasms. To date, less than 20 cases of squamous cell carcinoma with signet\u2010ring morphology have been described, mainly located on the skin. We present the case of a 73\u2010year\u2010old male with pleural effusion and a left lower lobe mass. The cytological study of the pleural effusion allowed the diagnosis of metastasis of squamous cell carcinoma, signet\u2010ring cell variant. The treatment of lung cancer in advanced stages requires a precise diagnosis that allows the best therapy to be offered to the patient, depending on the clinical stage and the positivity of the biomarkers, among others. Our patient died 18\u00a0months after the initial diagnosis.<\/jats:p>","DOI":"10.1002\/dc.25070","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T21:24:06Z","timestamp":1667337846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleural metastasis from pulmonary primary signet\u2010ring squamous cell carcinoma. Case report and literature review"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0154-5240","authenticated-orcid":false,"given":"H\u00e9ctor\u2010Enrique","family":"Torres\u2010Rivas","sequence":"first","affiliation":[{"name":"Pathology Department Hospital Universitario Central de Asturias  Oviedo Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-2646","authenticated-orcid":false,"given":"Miguel","family":"Ariza\u2010Prota","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Universitario Central de Asturias  Oviedo Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-6016","authenticated-orcid":false,"given":"Mar\u00eda de la Paz","family":"Gonz\u00e1lez Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Central de Asturias  Oviedo 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