{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:29:47Z","timestamp":1775503787121,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pemphigus vulgaris (PV) is a rare autoimmune disease characterized by blisters on the skin and mucous membrane. Since it often appears in the oral mucosa first, it may be diagnosed by oral mucosal cytology. Although the cytologic finding is characterized by acantholytic cells, that is, Tzanck cells, it is important to distinguish PV from neoplastic lesions of the oral mucosal epithelium, including differentiation from atypical parabasal\/basal cells, which appear in squamous cell carcinoma (SCC). In this study, we examined the cellular findings in two cases of PV and a case of well\u2010differentiated SCC with loss of epithelial cell cohesion. The samples were prepared using liquid\u2010based cytology, which showed small round\u2010shaped and deeply stained atypical, orangeophilic keratinocytes not only in SCC but also in PV, which made differentiation between the two difficult. However, Tzanck cells found in PV differ from the deep atypical parabasal\/basal cells of SCC, suggesting that the cell outline is indistinct and small protrusions and brush\u2010like structures are observed. This feature of Tzanck cells may be useful in cytological judgment.<\/jats:p>","DOI":"10.1002\/dc.25117","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T13:15:55Z","timestamp":1676034955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liquid\u2010based cytology for differentiating two cases of pemphigus vulgaris from oral squamous cell carcinoma"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-1536","authenticated-orcid":false,"given":"Satoshi","family":"Maruyama","sequence":"first","affiliation":[{"name":"Oral Pathology Section, Department of Surgical Pathology Niigata University Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Graduate School of Medical and Dental Sciences Faculty of Dentistry &amp; Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-6975","authenticated-orcid":false,"given":"Tatsuya","family":"Ab\u00e9","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Graduate School of Medical and Dental Sciences Faculty of Dentistry &amp; Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Sumita","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry and Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Tomihara","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry and Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-9517","authenticated-orcid":false,"given":"Jun\u2010ichi","family":"Tanuma","sequence":"additional","affiliation":[{"name":"Oral Pathology Section, Department of Surgical Pathology Niigata University Hospital  Niigata Japan"},{"name":"Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Graduate School of Medical and Dental Sciences Faculty of Dentistry &amp; Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90030-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13929"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21126"},{"key":"e_1_2_9_5_1","volume-title":"WHO Classification of Head and Neck Tumors","author":"Reibel J","year":"2017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23792"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23685"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12308"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13239"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001071"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.11.004"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.25117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:32:05Z","timestamp":1692455525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/dc.25117"],"URL":"https:\/\/doi.org\/10.1002\/dc.25117","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]},"assertion":[{"value":"2022-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}