{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:21:50Z","timestamp":1756462910057,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Syphilis is a sexually transmitted infection that causes serious health problems without treatment. Detection of syphilis is necessary to stop the spread of the infection. Cytological screeners and pathologists may experience fine\u2010needle aspiration cytology (FNAC) for syphilitic lymphadenitis; however, its characteristic cytological features are rarely reported. We present FNAC cytological features of syphilitic lymphadenitis in a case of a 21\u2010year\u2010old man. He presented with a sore throat and painful neck lymphadenopathy. His swollen and painful neck persisted even with antibiotic treatment. Necrotizing lymphadenitis and lymphoma were clinically suspected. FNAC was taken from the swollen lymph node. Cytologic findings of the specimen showed various inflammatory cells with small\u2010sized vessels arranged in a branching\/arborizing fashion. The vessels were surrounded by inflammatory cells, including plasma cells, neutrophils, and macrophages. Perivascular plasma cell cuffing was focally seen along with inconspicuous granulomas. Neutrophils appeared to involve the vascular wall. The cytological findings suggested syphilitic lymphadenitis, and clinical findings and serological tests confirmed primary syphilis with concomitant human immunodeficiency virus infection. Branching\/arborizing vessels associated with many plasma cells, vascular involvement of neutrophils, and granulomas may suggest syphilitic infection if the specimen is obtained via FNAC. (189\u00a0words).<\/jats:p>","DOI":"10.1002\/dc.25128","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:20:28Z","timestamp":1678796428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic utility of fine\u2010needle aspiration cytology in syphilitic lymphadenitis: A case report"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-0222","authenticated-orcid":false,"given":"Kenji","family":"Yorita","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Yasuoka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital  1\u20104\u201063\u201011, Hadaminami\u2010machi Kochi\u2010shi Kochi 780\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Notification trends among syphilis cases in Japan summary of syphilis notifications in Japan as at 5 October 2022 Department of Bacteriology I. National Institute of Infectious Diseases. [homepage on the Internet]. 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