{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:36:00Z","timestamp":1790789760436,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NUT carcinoma is an aggressive malignancy defined genetically by a balanced translocation of the <jats:italic>NUT<\/jats:italic> gene on chromosome 15q14, most commonly associated with the bromodomain\u2010containing protein 4 (<jats:italic>BRD4<\/jats:italic>) gene on 19p13.1 but less frequently with variant genes, including <jats:italic>BRD3<\/jats:italic> and <jats:italic>NSD\u20103<\/jats:italic>. We present a case report of a metastatic pulmonary NUT carcinoma found to have a <jats:italic>BRD3\u2010NUT<\/jats:italic> fusion and to have only focal pan\u2010cytokeratin staining. Biopsy of the pulmonary mass revealed dyscohesive cells with enlarged nuclei, prominent nucleoli and high nuclear to cytoplasmic ratio without areas of squamous differentiation. Initial immunohistochemical stains were positive for NUT, p63 and retained SMARCA4, while negative for Lu\u20105 (pan\u2010cytokeratin), TTF\u20101, p40, S100 protein, OCT\u20104, HMB\u201045, SMA, and PAX\u20108. Tempus \u00d7T assay revealed a <jats:italic>BRD3\u2010NUTM1<\/jats:italic> fusion gene. Post\u2010mortem analysis revealed an ill\u2010defined mass abutting the trachea and superior vena cava, as well as a perirenal mass.<\/jats:p>","DOI":"10.1002\/dc.25137","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T11:11:11Z","timestamp":1680779471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report of a <scp>pan\u2010cytokeratin<\/scp> negative <scp>NUT<\/scp> midline carcinoma of pulmonary origin, a <scp>BRD3\u2010NUT<\/scp> variant: Challenges in cytomorphologic presentation"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1705-1053","authenticated-orcid":false,"given":"Jay","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-5259","authenticated-orcid":false,"given":"Lisa","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chormanski","sequence":"additional","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Van Dellen","sequence":"additional","affiliation":[{"name":"Department of Pathology Brooke Army Medical Center  3551 Roger Brooke Dr San Antonio Texas 78219 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.06.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22342"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.052902"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12727"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00838.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000545"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210852"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24885"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3659"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318258f03b"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2018.1523852"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969211019532"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0206-z"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1153"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000082"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:22:26Z","timestamp":1692483746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/dc.25137"],"URL":"https:\/\/doi.org\/10.1002\/dc.25137","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,6]]},"assertion":[{"value":"2022-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}