{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:05:57Z","timestamp":1787241957188,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thoracocentesis of pleural effusion is a simple technique for pleural fluid examination through cytology. In addition to cytological examination to assess the nature of pleural fluid content, we can also perform more detailed examinations through cytoblocks of residual fluid. These paraffin\u2010embedded cytoblock samples are important because we can perform examinations as in other bioptic samples. In these samples, immunohistochemical and molecular analyses can be performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred fifty\u2010five cytological samples from patients with pleural effusion were examined. In cases in which the presence of malignant cells was identified in the cytological examination, as well as cases that were suspicious but not definitive for the presence of a malignant effusion, a cytoblock was prepared. Histological examination and immunohistochemical analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 255 cases with pleural effusion, 152 had the presence of malignant cells and 6 cases were suspicious, but uncertain for the presence of malignant cells, while 86 cases had inflammatory pleural effusion or other pathologies but were not malignant. After histological analysis of the cytoblock and immunohistochemical analysis, we identified 82 malignant tumors of the lung, 8 malignant tumors of the gastrointestinal tract, 15 malignant tumors of the breast, and 6 malignant tumors of the female genital tract, as well as 24 tumors of undetermined origin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cytoblocks are important for the diagnosis of the primary nature of malignant pleural effusions. The highest importance is primary lung tumors, as well as those tumors in which the primary site of the tumor cannot be determined clinically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.25201","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T04:37:28Z","timestamp":1691383048000},"page":"684-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of cytoblock on pleural effusion for diagnosis of malignant disease"],"prefix":"10.1002","volume":"51","author":[{"given":"Labinot","family":"Shahini","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Prishtina \u201cHasan Prishtina\u201d  Prishtina Kosovo"},{"name":"Institute of Pathology University Clinical Centre of Kosovo  Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Hoxha","sequence":"additional","affiliation":[{"name":"Clinic for Lung Disease University Clinical Centre of Kosovo  Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flamur","family":"Marku","sequence":"additional","affiliation":[{"name":"Clinic for Lung Disease University Clinical Centre of Kosovo  Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Besim","family":"Morina","sequence":"additional","affiliation":[{"name":"Clinic for Lung Disease University Clinical Centre of Kosovo  Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valon","family":"Cena","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Clinical Centre of Kosovo  Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-3466","authenticated-orcid":false,"given":"Klodete","family":"Kabashi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Kolegji Rezonanca  Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Surgical Department Gjilan Regional Hospital  Gjilan Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"113","article-title":"Evaluation of the contribution of fine\u2010needle non\u2010aspiration cytology to diagnosis in cases with pulmonary malignant lesions","volume":"52","author":"Yilmaz S","year":"2022","journal-title":"Turk J Med Sci"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010731"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.23.12.417"},{"key":"e_1_2_10_5_1","first-page":"1211","article-title":"Diagnostic approach to pleural effusion in adults","volume":"73","author":"Porcel J","year":"2006","journal-title":"Am Fam 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hormone receptors, MIB\u20101, p53, and c\u2010erb\u2010B2 expression on breast cancer: comparison of immunohistochemistry on cell block and fine\u2010needle aspiration and tissue sample, in Northwest Iran","volume":"3","author":"Mardanpour K","year":"2012","journal-title":"Caspian J Intern Med"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/JOC.JOC_157_19"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.25259\/CMAS_02_14_2021"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.10.016"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"173","article-title":"The diagnostic significance of cytological and histological examination of secretions, washout materials, catheterization and brush biopsy materials in the diagnosis of malignant bronchopulmonary diseases","volume":"15","author":"Habanec B","year":"1979","journal-title":"Cesk 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