{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:51:38Z","timestamp":1747147898283,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cytologic diagnosis of acinic cell carcinoma (ACC) can be challenging due to its polymorphous appearance and sharing cytomorphologic characteristics with other benign and malignant neoplasms as well as non\u2010neoplastic diseases, even though various histomorphological aspects of ACC have been documented. We presented a 39\u2010year\u2010old female patient applied with right pre\u2010auricular parotid swelling spreading infra\u2010auricular region which was gradually increased in size for 3\u2009months. Ultrasonographic examination revealed hypoechoic well\u2010circumscribed mass with 17\u2009\u00d7\u200922\u2009\u00d7\u200929\u2009mm size. Magnetic resonance imaging revealed intra\u2010parotid solid lesion with cystic areas, slightly hypointense on T1 and hyperintense on T2 weighted images. The mass was pushing the retromandibular vein medially, still lateral to it in the caudal images, but in dumbbell\u2010shape spreading through parapharyngeal space in superiorly cranial images. Fine\u2010needle aspiration cytology was also performed with guidance of ultrasonography. The cytological examination of the lesion was characterized by the predominance of heterogeneous lymphoid cells, clusters of epithelial cells with a variety of cytologic appearances, including granular, transparent, vacuolated, and oncocytic, and the presence of numerous naked nuclei with a protein\u2010like foamy background. Due to intense lymphocytic inflammation, it was considered as benign primary parotid tumor such as Warthin's tumor. The excision material was examined histopathologically. Immunohistochemical analysis showed that this carcinoma was positive for DOG1, SOX10, cytokeratin 7 and negative for mammaglobin. This salivary gland tumor was reported as a rare variant of ACC with lymphoid\u2010rich stroma. To improve the diagnostic accuracy, various morphological aspects of ACC should be considered in the pathological practice.<\/jats:p>","DOI":"10.1002\/dc.25233","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T09:26:00Z","timestamp":1696584360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acinic cell carcinoma mimicking Warthin's tumor: A diagnostic challenge on fine\u2010needle cytology"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-3127","authenticated-orcid":false,"given":"Busra","family":"Yaprak Bayrak","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-9975","authenticated-orcid":false,"given":"Murat","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"191","article-title":"Acinic cell carcinoma of the parotid gland: a diagnostic dilemma on cytology","volume":"41","author":"Sharma A","year":"2019","journal-title":"Malays J Pathol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24571"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199705)16:5<402::AID-DC5>3.0.CO;2-D"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01492-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90082-4"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"1770","article-title":"Well\u2010differentiated acinic cell carcinoma with lymphoid stroma associated with osteoclast\u2010like giant cells of the parotid gland in children: a case report and literature review","volume":"11","author":"Liu Z","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1995.tb00574.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.25259\/Cytojournal_1_2021"},{"key":"e_1_2_8_10_1","article-title":"Cytological features of mammary analogue secretory carcinoma of the parotid gland in a 15\u2010year\u2010old girl: a case report with review of the literature","volume":"2015","author":"Inaba T","year":"2015","journal-title":"Case Rep Pathol"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"357","article-title":"Fine needle aspiration cytology of mucoepidermoid carcinoma. A diagnostic problem","volume":"35","author":"Kumar N","year":"1991","journal-title":"Acta Cytol"},{"issue":"4","key":"e_1_2_8_12_1","first-page":"516","article-title":"Fine needle aspiration cytology in two cases of well\u2010differentiated acinic\u2010cell carcinoma of the parotid gland. Discussion of diagnostic criteria","volume":"29","author":"Palma O","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199711)17:5<347::AID-DC7>3.0.CO;2-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2438"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T11:21:42Z","timestamp":1702725702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,6]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/dc.25233"],"URL":"https:\/\/doi.org\/10.1002\/dc.25233","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2023,10,6]]},"assertion":[{"value":"2023-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}