{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:30:29Z","timestamp":1771878629473,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extranodal NK\/T\u2010cell lymphoma (ENKTL), nasal type, is often seen in the head and neck region, but there have been rare instances of this disease with initial presentation as a lesion in the oral mucosa. The patient, a woman in her seventh decade of life, presented with an ulcer in the maxillary gingiva, and scraping cytology and biopsy were performed. Cytological specimens showed solitary or small aggregating cells with marked atypia in a necrotic background. Tumor cells were detected that had various nuclear shapes and azure granules in the cytoplasm. Biopsy showed that the tumor cells had diffusely infiltrated or interdigitated into the subepithelium. Immunohistochemistry revealed that the tumor cells had T\u2010 and NK cell phenotypes and were Epstein\u2013Barr virus\u2010encoded small RNA (EBER) positive, leading to a diagnosis of ENKTL. Thus, when nonepithelial tumor cells in a necrotic background and prominent atypia are found, as in this case, it is important to carefully observe for azurophil granules in the cytoplasm for differential diagnosis considerations.<\/jats:p>","DOI":"10.1002\/dc.25244","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:08:02Z","timestamp":1698397682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of extranodal NK\/T\u2010cell lymphoma, nasal type, diagnosed by scraping cytology of the maxillary gingiva"],"prefix":"10.1002","volume":"52","author":[{"given":"Hiroe","family":"Niwa","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Medical Technology, Nanto Municipal Hospital  Nanto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Medical Technology, Nanto Municipal Hospital  Nanto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iyo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Dentistry Oral and Maxillofacial Surgery, Nanto Municipal Hospital  Nanto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johji","family":"Imura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kumagaya General Hospital  Kumagaya Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"285","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization (WHO), Tumors of Haematopoietic and Lymphoid Tissues","author":"World Health Organization Classification of Tumours","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi037"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01108.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199304000-00010"},{"key":"e_1_2_8_6_1","first-page":"754","article-title":"Cytotoxic granular protein expression, Epstein\u2010Barr virus strain type, and latent membrane protein\u20101 oncogene deletions in nasal T\u2010lymphocyte\/natural killer cell lymphomas from Mexico","volume":"11","author":"Elenitoba\u2010Johnson KS","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103237"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.11.2010.3511"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050417"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5843\/jsot.27.119"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01182-8"},{"key":"e_1_2_8_12_1","first-page":"101","article-title":"Extranodal NK\/T cell lymphoma with destruction of the uvulae: a case report","volume":"29","author":"Jabbari Azad F","year":"2017","journal-title":"Iran J Otorhinolaryngol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227160"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326574"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10885"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12705"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T05:19:39Z","timestamp":1705900779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/dc.25244"],"URL":"https:\/\/doi.org\/10.1002\/dc.25244","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"assertion":[{"value":"2023-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}