{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:51:46Z","timestamp":1747147906702,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dedifferentiated\/undifferentiated melanoma (DM\/UM) is a distinct subtype of malignant melanoma that tends to lose all melanocytic markers of differentiation. DM\/UM pose major diagnostic challenges as they could be easily confused with UM sarcoma or carcinoma, thus necessitating the use of molecular studies such as Next Generation Sequencing (NGS) for detecting melanoma\u2010compatible mutations to confirm such diagnosis. The capability of performing NGS molecular studies on small biopsy material with confirmation of adequacy via rapid on\u2010site evaluation (ROSE) has tremendous value in diagnosing DM\/UM. Herein, we present the first reported case of metastatic DM\/UM to the gall bladder arising in a 60\u2010year\u2010old female with a prior history of right knee melanoma. We also shed light on the cytomorphology of DM\/UM, review the literature on such a challenging entity, and emphasize the crucial role of molecular testing in their diagnosis.<\/jats:p>","DOI":"10.1002\/dc.25292","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T13:59:10Z","timestamp":1708523950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomorphology of metastatic dedifferentiated\/undifferentiated melanoma to the gallbladder: A case report and review of literature"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1620-2016","authenticated-orcid":false,"given":"Shaymaa","family":"Hegazy","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarine","family":"Kamaluddin","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Naous","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1111\/cup.13857"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1038\/modpathol.3800516"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1097\/DAD.0b013e31828a2ec5"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1016\/j.cell.2015.05.044"},{"unstructured":"National Comprehensive Cancer Network (NCCN).NCCN website.2021Accessed April 30http:\/\/www.nccn.org\/index.asp","key":"e_1_2_7_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1016\/j.jaad.2016.06.051"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1097\/PAS.0000000000001134"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1097\/PAS.0000000000001645"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1097\/PAS.0000000000000527"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1016\/j.ctrv.2020.102060"},{"key":"e_1_2_7_12_1","article-title":"Dedifferentiated and undifferentiated neoplasms: a conceptual approach","volume":"5","author":"Baraban E","year":"2020","journal-title":"Semin Diagn Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1097\/PAS.0000000000002125"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1002\/cncy.22488"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1007\/s10238-015-0353-6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1002\/ccr3.121"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.9738\/INTSURG-D-13-00143.1"},{"volume-title":"\u00dcber die Physiologische und Pathologische Melanin Pigmentierung und den Epithelialen Ursprung der Melanoblastome","year":"1907","author":"Wieting J","key":"e_1_2_7_18_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1158\/2159-8290.CD-17-0151"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T12:37:23Z","timestamp":1712147843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/dc.25292"],"URL":"https:\/\/doi.org\/10.1002\/dc.25292","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2024,2,21]]},"assertion":[{"value":"2023-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}