{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:34:37Z","timestamp":1764646477840,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A mesonephric\u2010like endometrial adenocarcinoma (ML\u2010EAC) is very rare and has a worse prognosis than other endometrial carcinomas. We describe an ML\u2010EAC and report our endometrial cytological findings. A 76\u2010year\u2010old woman presented with irregular genital bleeding and a uterine mass. Endometrial cytology revealed atypical cylindrical or spindle\u2010shaped cells in the form of small aggregates or solitary cells. The cell aggregates exhibited irregularly stacked papillary structures, small glandular structures, and fenestrated structures. The atypical cells had a nucleus with fine\u2010granular chromatin and a granular cytoplasm, and nuclear grooves and intranuclear pseudo\u2010inclusions were present. Hyaline globules were observed in the glandular lumens and in the background. The presumptive histological type was an adenocarcinoma, but the cytological features were different from those of an endometrioid carcinoma. A histological examination of the endometrial biopsy revealed an adenocarcinoma, and a simple hysterectomy was performed. A grayish\u2010white elevated mass measuring 90\u2009mm\u2009\u00d7\u200970\u2009mm\u2009\u00d7\u200940\u2009mm was observed on the uterine corpus in the hysterectomy specimen. Histologically, the tumor proliferated as complex tubular structures containing eosinophilic colloid\u2010like materials and trabecular structures. The tumor cells were diffuse and positive for GATA\u20103 and partially positive for thyroid transcription factor\u20101. Estrogen and progesterone receptors were negative. An ML\u2010EAC was diagnosed. The tumor was invasive and extended beyond one\u2010half of the muscle layer with a high degree of vascular invasion. In conclusion, we need to focus on the various shapes of the cell aggregate, nuclear grooves, and intranuclear pseudo\u2010inclusions of tumor cells to distinguish an ML\u2010EAC from other endometrial carcinomas in endometrial cytology.<\/jats:p>","DOI":"10.1002\/dc.25300","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T05:13:27Z","timestamp":1709874807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endometrial cytological findings for a mesonephric\u2010like endometrial adenocarcinoma: A case report"],"prefix":"10.1002","volume":"52","author":[{"given":"Hirotaka","family":"Omine","sequence":"first","affiliation":[{"name":"Department of Pathology Dokkyo Medical University Hospital  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-4588","authenticated-orcid":false,"given":"Kazuyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Pathology Dokkyo Medical University Hospital  Mibu Japan"},{"name":"Department of Diagnostic Pathology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9633-0180","authenticated-orcid":false,"given":"Natsuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Dokkyo Medical University Hospital  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pathology Dokkyo Medical University Hospital  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pathology Dokkyo Medical University Hospital  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Dokkyo Medical University Hospital  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadzki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"264","volume-title":"WHO Classification of Tumours Editorial Board. Female Genital Tumors","author":"Singh H","year":"2020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001401"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368162"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001193"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22160"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25111"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2012.00959.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00013"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T12:47:16Z","timestamp":1714567636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/dc.25300"],"URL":"https:\/\/doi.org\/10.1002\/dc.25300","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"2024-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}