{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:33:46Z","timestamp":1790829226404,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This report describes the cytologic features of a recently described <jats:italic>MXD4::NUTM1<\/jats:italic>\u2010rearranged colonic sarcoma metastatic to the midclavicular soft tissue. Thirteen years ago, a 65\u2010year\u2010old woman presented with a cecal mass and subsequent liver mass. The cecal mass was diagnosed as malignant undifferentiated spindled and epithelioid neoplasm based on morphology and lack of tumor immunoreactivity with a panel of epithelial, smooth muscle, skeletal, melanoma, hematologic, and GIST markers. The liver mass showed morphologic and immunophenotypic similarity to the epithelioid component of the patient's cecal mass, albeit devoid of the spindled component. Fine needle aspiration of the midclavicular soft tissue mass showed singly scattered to clustered epithelioid to rhabdoid tumor cells with centrally to eccentrically located nuclei, prominent nucleoli, and moderate eosinophilic cytoplasm. Immunohistochemical stains performed on the concurrent biopsy showed the tumor cells were positive for NUT and negative for all other additional markers with retained normal expression of SMARCA2 and SMARCA4. Next\u2010generation sequencing showed the presence of <jats:italic>MXD4::NUTM1<\/jats:italic> gene fusion. Due to the identical cytomorphologic findings with the epithelioid component of the patient's prior cecal and liver masses, the tumor was deemed as consistent with a <jats:italic>NUTM1<\/jats:italic>\u2010rearranged sarcoma. To our knowledge, this case represents the first reported cytologic features of a <jats:italic>NUTM1<\/jats:italic>\u2010rearranged sarcoma on fine needle aspiration. Familiarity with the cytologic features, inclusion of this entity in the differential diagnosis of tumors with epithelioid and\/or rhabdoid morphology, and performance of ancillary tests (immunohistochemistry and molecular) will be helpful in arriving at the right diagnosis.<\/jats:p>","DOI":"10.1002\/dc.25320","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:58:50Z","timestamp":1712732330000},"page":"342-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytomorphology of metastatic colonic <i>MXD4::NUTM1<\/i>\u2010rearranged sarcoma"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7659-3349","authenticated-orcid":false,"given":"Zachary Alan","family":"Wilkinson","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio 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