{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:47:44Z","timestamp":1767066464480,"version":"3.44.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary mucinous cystadenocarcinoma (MCA) of the breast is a rare variant of breast carcinoma. A 68\u2010year\u2010old female patient presented to the general surgery clinic with pain and swelling in the right breast. A mass was detected in the upper outer quadrant, and a fine\u2010needle aspiration biopsy was performed. The May\u2010Gr\u00fcnwald Giemsa stained slides showed aggregates of mucin\u2010rich pleomorphic cells with large nuclei in a mucinous background containing discohesive single cells. The Papanicolaou stain revealed a papillary structure composed of malignant epithelial cells in a necrotic background. A modified radical mastectomy was performed, and upon gross examination, two tumors were discovered in the central and upper outer quadrants. The first tumor, located centrally, was identified as invasive lobular breast carcinoma. The second tumor was an MCA with cytokeratin 7(+) and cytokeratin 20(\u2212), and was determined to be the primary MCA of the breast based on clinical and radiological information. Immunohistochemistry revealed that the tumor cells were negative for estrogen receptor and progesterone receptor, and HER2 was 2+. Fluorescence in situ hybridization analysis detected HER2 gene amplification. During the 72\u2010month follow\u2010up, there were no findings compatible with recurrence or new metastasis. Although primary MCA is rare, it causes differential diagnosis problems and has different biological behaviors.<\/jats:p>","DOI":"10.1002\/dc.25364","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:01:13Z","timestamp":1717520473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>HER2<\/scp>\u2010positive mucinous cystadenocarcinoma of the breast coexisting with invasive lobular carcinoma: A case report and review of the literature"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-4404","authenticated-orcid":false,"given":"Ismail","family":"Guzelis","sequence":"first","affiliation":[{"name":"Department of Pathology Izmir Buca Seyfi Demirsoy Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul Bolat","family":"Kucukzeybek","sequence":"additional","affiliation":[{"name":"Department of Pathology Ataturk Training and Research Hospital, Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Uyaroglu","sequence":"additional","affiliation":[{"name":"Department of Pathology Ataturk Training and Research Hospital, Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melek Bekler","family":"Gokova","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ataturk Training and Research Hospital, Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulten","family":"Sezgin","sequence":"additional","affiliation":[{"name":"Deparment of Radiology Ataturk Training and Research Hospital, Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuksel","family":"Kucukzeybek","sequence":"additional","affiliation":[{"name":"Department of Oncology Ataturk Training and Research Hospital, Izmir Katip Celebi University  Izmir 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