{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:28:50Z","timestamp":1749544130901,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273327"],"award-info":[{"award-number":["82273327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Fumarate hydratase (FH)\u2010deficient renal cell carcinoma (RCC) is a rare, aggressive, hereditary subtype of renal cancer that requires careful diagnostic considerations. We report a case of a 33\u2010year\u2010old Asian woman who presented with a 20\u2010day history of hematuria. Imaging studies revealed a solid tumor in the lower pole of the right kidney with lymph node metastases. Urinary cytology revealed benign squamous cells, inflammatory cells, and atypical epithelial cells, suggestive of high\u2010grade urothelial carcinoma. Following a right nephrectomy, the tumor displayed papillary structures composed of cells exhibiting atypical, elongated nuclei with eosinophilic nucleoli and peripheral halos. Immunohistochemical staining demonstrated negative FH expression. Genetic analysis identified a somatic missense mutation in the FH gene, confirming the diagnosis of FH\u2010deficient RCC. This case highlights the importance of integrating cytological, histological, and genetic analyses for accurate diagnosis of FH\u2010deficient RCC.<\/jats:p>","DOI":"10.1002\/dc.25409","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:34:52Z","timestamp":1728635692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pitfalls in Urine Cytology: A Case of Fumarate Hydratase\u2010Deficient Renal Cell Carcinoma Initially Diagnosed as High\u2010Grade Urothelial Carcinoma"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3914-4144","authenticated-orcid":false,"given":"Kai","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing KingMed Medical Laboratory Co., Ltd.  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-1937","authenticated-orcid":false,"given":"Qiu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"issue":"10","key":"e_1_2_7_2_1","first-page":"1339","article-title":"Fumarate Hydratase\u2013Deficient Renal Cell Carcinoma Is Strongly Correlated With Fumarate Hydratase Mutation and Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome","volume":"40","author":"Trpkov K.","year":"2016","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31804375b8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13183"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000719"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100303"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22071"},{"key":"e_1_2_7_8_1","first-page":"78","volume-title":"Urinary and Male Genital Tumours","author":"WHO Classifcation of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22789"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2018.04.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13322"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-88686-8"},{"key":"e_1_2_7_13_1","first-page":"246","volume-title":"Diagnostic Pathology: Cytopathology","author":"Mody D. 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