{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:59:02Z","timestamp":1767135542732,"version":"build-2238731810"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006338","name":"Vlaamse Interuniversitaire Raad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023732","name":"Sefako Makgatho Health Sciences University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The South African Cervical Cancer Prevention and Control Policy was updated in June 2017, recommending liquid\u2010based cytology (LBC) as the preferred screening method and the investigation of self\u2010sampling for cervical cancer screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the performance of the Self Collection Cervical Health Screening Kit [SelfCerv (applicator tampon)] to the Cervex\u2010Brush Combi for cytology screening. The study further aimed to compare high\u2010risk (hr\u2010) human papillomavirus (HPV) and LBC test results from both methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 446 paired samples, comprising self\u2010collected (SelfCerv) and healthcare provider\u2010collected (Cervex\u2010Brush Combi) samples from women aged \u2265\u200918\u2009years attending gynaecology outpatient clinics at a tertiary hospital in Pretoria, South Africa. LBC slides were prepared using the ThinPrep 5000 processor and manually stained with Hematoxylin and Eosin (H&amp;E). Detection of 14 hr\u2010HPV types was performed using the Abbott RealTime HR\u2010HPV assay. Statistical analyses were performed using STATA version 17.0 (Stata Corp., College Station, Texas, USA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A statistically significant difference in cervical cytology detection between the two methods was observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0025). The Cervex\u2010Brush Combi was more effective in collecting endocervical cells (73.4%; 95% CI: 69.0\u201377.9) compared to the SelfCerv applicator tampon (7.3%; 95% CI: 4.7\u20139.9); (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cytological abnormalities were detected in 65.4% (136\/208) of participants who tested positive for hr\u2010HPV by healthcare provider sampling compared to 40.8% (84\/206) by self\u2010sampling. A fair agreement (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      : 0.35) with a concordance rate of 96.2% (95% CI: 94.4\u201398.0) was observed for specimen adequacy and diagnosis parameters [\n                      <jats:italic>\u03ba<\/jats:italic>\n                      : 0.34, with a concordance rate of 67.7% (95% CI: 63.2\u201372.1)] between the two methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of this study do not support the implementation of applicator tampon\u2010based self\u2010collection as a method for cytology\u2010based cervical cancer screening.<\/jats:p>\n                  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Varster","family":"Nkwinika","sequence":"additional","affiliation":[{"name":"Department of Virological Pathology Sefako Makgatho Health Sciences University  Pretoria South Africa"},{"name":"South African Vaccination and Immunization Centre Sefako Makgatho Health Sciences University  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tebogo Loraine","family":"Mashishi","sequence":"additional","affiliation":[{"name":"Department of Virological Pathology Sefako Makgatho Health Sciences University  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kgotlaethata Aaron","family":"Molefi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sefako Makgatho Health Sciences University  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thembeni Lucia","family":"Msibi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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