{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:27:39Z","timestamp":1788406059468,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The measurement of Calcitonin (Ctn) in fine\u2010needle aspiration (FNA) washout fluids (FNA\u2010Ctn) has demonstrated excellent sensitivity, significantly higher than FNA cytology, in detecting medullary thyroid carcinoma (MTC). However, the absence of a fixed cutoff value for FNA\u2010Ctn poses a limitation. This study aimed to investigate whether the sensitivity of FNA\u2010Ctn in detecting MTC varies with different cutoffs reported in the literature. A single\u2010centre series of MTCs was retrospectively reviewed. The preoperative FNA\u2010Ctn levels were re\u2010evaluated using various thresholds previously reported in the literature, and the corresponding FNA\u2010Ctn sensitivities were compared. Twenty\u2010one MTCs were included (69% women; median age 59\u2009years; median serum Ctn value 86\u2009pg\/mL; median MTC major diameter 10\u2009mm). The median FNA\u2010Ctn value was 2000\u2009pg\/mL (interquartile range 49\u2013250). MTCs nodules were assessed at high risk (ACR TI\u2010RADS 5) in 50% of cases, while 47.6% were cytologically malignant. Additionally, 42.9% of cases were assessed as stage III according to Union for International Cancer Control staging system (UICC). Serum Ctn was significantly lower in stage I (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). FNA\u2010Ctn was positively correlated with serum Ctn (Rho\u2009=\u20090.45; <jats:italic>p<\/jats:italic>\u2009=\u20090.04), while ACR TI\u2010RADS assessment with MTC stage (Rho\u2009=\u20090.69; <jats:italic>p<\/jats:italic>\u2009=\u20090.003). FNA\u2010Ctn sensitivity ranged from 95% to 100% based on the previously proposed FNA\u2010Ctn cutoffs. The high sensitivity of FNA\u2010Ctn in detecting MTC did not significantly differ when applying the previously proposed cutoffs. Given the absence of a universally applicable FNA\u2010Ctn decisional threshold, institutions should establish their own diagnostic cutoffs. Future guidelines should incorporate these concepts to enhance clinical decision\u2010making and patient outcomes.<\/jats:p>","DOI":"10.1002\/dc.25440","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T06:55:43Z","timestamp":1736578543000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High Sensitivity of Fine\u2010Needle Aspiration Calcitonin in Detecting Medullary Thyroid Carcinoma Is Independent of Predefined Decisional Thresholds"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-2388","authenticated-orcid":false,"given":"Sium","family":"Wolde Sellasie","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, CTO Andrea Alesini Hospital, Department of Biomedicine and Prevention University of Rome Tor Vergata  Rome Italy"},{"name":"PhD School of Applied Medical\u2010Surgical Sciences University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Amendola","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, CTO Andrea Alesini Hospital, Department of Biomedicine and Prevention University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Guidobaldi","sequence":"additional","affiliation":[{"name":"UOC of Pathologic Anatomy and Cytodiagnostic Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pedicini","sequence":"additional","affiliation":[{"name":"Thyroid Endocrine Surgery Sant'Eugenio Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Nardone","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, CTO Andrea Alesini Hospital, Department of Biomedicine 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Scappaticcio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases AOU University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Leoncini","sequence":"additional","affiliation":[{"name":"Servizio di Radiologia e Radiologia Interventistica, Istituto di Imaging Della Svizzera Italiana (IIMSI) Ente Ospedaliero Cantonale (EOC)  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Uccioli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, CTO Andrea Alesini Hospital, Department of Biomedicine and Prevention University of Rome Tor Vergata  Rome 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