{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:09:55Z","timestamp":1770523795497,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Globally, cervical cytology continues to serve as the cornerstone of cervical cancer screening programs, but WHO 2021 guidelines advocate HPV DNA testing as the primary screening modality due to its heightened sensitivity. This method necessitates additional triage with cytology or colposcopy to detect precancerous lesions. Hormonal shifts and anatomical alterations in postmenopausal women may impact diagnostic outcomes in either modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the spectrum of cytological lesions in HPV\u2010positive postmenopausal women to detect precancerous lesions as part of cervical cancer screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Conventional cytology smears of high\u2010risk HPV\u2010positive postmenopausal women were reported according to The Bethesda System 2014. Results of follow\u2010up biopsies of the positive smears were recorded, and cyto\u2010histological correlation was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The retrospective study included conventional cytology smears of 124 postmenopausal women positive for high\u2010risk HPV DNA with a mean age of 52\u2009years. Of the 124 cases, 68 were positive for HPV 16 and\/or 18, and 56 were positive for other high\u2010risk HPV. On cytology, 78% were negative for intraepithelial lesions. HSIL+ lesions were noted in 12%, and low\u2010grade lesions were noted in 10% of smears with HPV16\/18 predominance. Follow\u2010up biopsies of 17 smears revealed SCC in two cases, HSIL+ in 11 cases, LSIL in 2, and 2 were negative\/benign lesions. Of the cyto\u2010histological discordant cases, four were upgraded on review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cytology is a useful triage tool in detecting preinvasive and early invasive tumors in HPV DNA\u2010positive postmenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.25456","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:37:01Z","timestamp":1741761421000},"page":"246-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytology Triage for <scp>HPV<\/scp>\u2010Positive Postmenopausal Women in a Setting of Cervical Cancer Screening"],"prefix":"10.1002","volume":"53","author":[{"given":"Aparna","family":"Chacko","sequence":"first","affiliation":[{"name":"Department of Pathology St. John's Medical College  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishaka C.","family":"Bidkar","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology St. John's Medical College Hospital  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology St. John's Medical College Hospital  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-9451","authenticated-orcid":false,"given":"Julian","family":"Crasta","sequence":"additional","affiliation":[{"name":"Department of Pathology St. John's Medical College  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"WHO Guideline for Screening and Treatment of Cervical Pre\u2010Cancer Lesions for Cervical Cancer Prevention","year":"2021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0361\u2010090x(03)00104\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12718"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.076"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14168"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12010210"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.07.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14162"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010019\u20101145\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"1","article-title":"Global Prevalence of Cervical Human Papillomavirus in Women Aged 50\u2009Years and Older With Normal Cytology: A Systematic Review and Meta\u2010Analysis","volume":"6","author":"Osmani V.","year":"2024","journal-title":"Lancet Microbe"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971\u20105851.96961"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"186","article-title":"Concurrent Evaluation of Visual, Cytological and HPV Testing as Screening Methods for the Early Detection of Cervical Neoplasia in Mumbai, India","volume":"83","author":"Shastri S. S.","year":"2005","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23032"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju423"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.6026\/97320630016452"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T12:04:43Z","timestamp":1743595483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/dc.25456"],"URL":"https:\/\/doi.org\/10.1002\/dc.25456","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"2025-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}