{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:44:54Z","timestamp":1749447894722,"version":"3.40.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lung adenocarcinoma is a common malignancy that can metastasize. The lung is also a common site for metastasis from other sites. Prompt and accurate diagnosis is critical for patient management. The diagnosis of lung adenocarcinoma can be occasionally challenging due to overlapping clinical and pathological features with adenocarcinomas from other origins. We present three cases of lung adenocarcinomas with concomitant metastatic adenocarcinomas of different primaries in the same endobronchial ultrasound\u2010guided fine\u2010needle aspiration (EBUS\u2010FNA) or core biopsy procedures. The first case showed metastatic ROS\u2010rearranged lung adenocarcinoma and metastatic ampullary adenocarcinoma involving different mediastinal lymph nodes, respectively, in a patient with no previous history of malignancy. The second case showed metastatic lung adenocarcinoma with MET exon 14 deletion and metastatic breast adenocarcinoma involving different mediastinal lymph nodes, respectively, in a patient with a previous history of breast carcinoma. The third case showed metastatic prostatic adenocarcinoma to a pre\u2010existing lung mucinous adenocarcinoma in a patient with a previous history of prostatic adenocarcinoma. Our report highlights attention to details, judicious use of immunostains, and ancillary molecular studies in complex pathology cases. Cytohistological findings are also correlated with molecular test results.<\/jats:p>","DOI":"10.1002\/dc.25460","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:54:40Z","timestamp":1741701280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytologic Diagnoses of Lung Adenocarcinoma With Concomitant Metastasis From a Different Primary: A Case Series"],"prefix":"10.1002","volume":"53","author":[{"given":"Robert","family":"Pei","sequence":"first","affiliation":[{"name":"University of Virginia School of Medicine Inova Campus  Falls Church Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane M.","family":"Woods","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine Inova Campus  Falls Church Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-1586","authenticated-orcid":false,"given":"Brant G.","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine Inova Campus  Falls Church Virginia USA"},{"name":"Department of Pathology Inova Fairfax Hospital  Falls Church Virginia USA"},{"name":"Department of Pathology Georgetown University Medical Center  Washington DC USA"},{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318206a221"},{"volume-title":"Thoracic Tumours, WHO Classification of Tumours","year":"2021","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_4_3_1"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182758fe6"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14311"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181589f72"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213424.38503.aa"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.87"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201021\u20100423"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.03.023"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4971"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101123"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp\u20102022\u2010208583"},{"issue":"6","key":"e_1_2_4_14_1","first-page":"2108","article-title":"Homozygous Deletion of CDKN2A and Codeletion of the Methylthioadenosine Phosphorylase Gene in the Majority of Pleural Mesotheliomas","volume":"9","author":"Illei P. B.","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13385"},{"key":"e_1_2_4_15_2","unstructured":"Erratum in: Nature. 2014 Oct 9;514(7521):262. Rogers K [corrected to Rodgers K]. Erratum in: Nature. 2018 Jul;559(7715):E12.https:\/\/doi.org\/10.1038\/s41586\u2010018\u20100228\u20106."},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.06.022"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182a471c3"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T10:46:57Z","timestamp":1746096417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/dc.25460"],"URL":"https:\/\/doi.org\/10.1002\/dc.25460","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"2024-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}