{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:10:04Z","timestamp":1746097804450,"version":"3.40.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often challenging to diagnose due to its morphological resemblance to other malignancies. Diagnosis is typically confirmed by immunohistochemistry (IHC), with most cases being positive for both neuroendocrine and epithelial markers, particularly the characteristic dot\u2010like cytoplasmic pattern seen with Cytokeratin 20 (CK20). This case report describes a 68\u2010year\u2010old male with MCC originating in the left elbow, who developed pleural metastasis 10\u2009months after initial diagnosis and 4\u2009months following a pathologic complete response. IHC analysis confirmed MCC in the pleural fluid with positive markers including: CK20, chromogranin, synaptophysin, MCC polyomavirus, and SATB2, the latter emerging as a valuable adjunct in distinguishing MCC from other neuroendocrine tumors.<\/jats:p>","DOI":"10.1002\/dc.25472","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T09:27:58Z","timestamp":1743240478000},"page":"308-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleural Metastasis of Merkel Cell Carcinoma"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6880-9071","authenticated-orcid":false,"given":"Sina","family":"Maghsoudlou","sequence":"first","affiliation":[{"name":"Department of Pathology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Pusztaszeri","sequence":"additional","affiliation":[{"name":"Department of Pathology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Saieg","sequence":"additional","affiliation":[{"name":"Department of Pathology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000482"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620040075020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001232"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152586"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181a12f5a"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.04.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010020\u201008587\u20103"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2781"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24882"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28088"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20106413\u20101\u20105"},{"issue":"3","key":"e_1_2_6_13_1","first-page":"397","article-title":"Cytology of Metastatic Neuroendocrine (Merkel\u2010Cell) Carcinoma in Pleural Fluid: A Case Report","volume":"29","author":"Watson C. 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