{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:59:51Z","timestamp":1792803591725,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lymphomatoid granulomatosis (LYG) is a rare EBV\u2010driven, extra\u2010nodal, angiocentric, and angio\u2010destructive lymphoproliferative disorder. The lungs are the most common site of involvement. We describe a case of LYG where the diagnosis was established based on fine needle aspiration. The case is of a 58\u2010year\u2010old female with a history of endometrial carcinoma, who presented with right upper lobe and right middle lobe pulmonary nodules which were identified on a surveillance computed tomography (CT) scan of the chest. The patient underwent an endobronchial ultrasound\u2010guided fine needle aspiration, and a cytologic examination showed mixed inflammatory infiltrate with histiocyte and small lymphocyte predominance and scattered large atypical cells. Immunohistochemical analysis showed that the large atypical cells were positive for CD30, PAX5, and MUM1. In\u00a0situ hybridization for Epstein\u2013Barr virus\u2010encoded RNA was found to be positive in the atypical cells. The patient was started on treatment with peginterferon alfa\u20102a. We also discuss the differential diagnosis of LYG and review the available literature.<\/jats:p>","DOI":"10.1002\/dc.25475","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:48:36Z","timestamp":1744372116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytologic Diagnosis of Lymphomatoid Granulomatosis, A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"53","author":[{"given":"Mohamed","family":"Eltahir","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javeryah","family":"Safi","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2010Interventional Pulmonology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-1586","authenticated-orcid":false,"given":"Brant G.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Classification of Tumours Editorial Board Haematolymphoid Tumours","author":"Ott G.","year":"2024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000328"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(72)80005-4"},{"issue":"4","key":"e_1_2_7_5_1","first-page":"435","article-title":"Detection of Epstein\u2010Barr Virus Genomes in Lymphomatoid Granulomatosis: Analysis of 29 Cases by the Polymerase Chain Reaction Technique","volume":"3","author":"Katzenstein A. 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A Case Report","volume":"36","author":"Williams W. L.","year":"1992","journal-title":"Acta Cytologica"},{"issue":"2","key":"e_1_2_7_17_1","first-page":"205","article-title":"Fine Needle Aspiration Biopsy of a Cutaneous Relapse of Lymphomatoid Granulomatosis. A Case Report","volume":"37","author":"Vargas J.","year":"1993","journal-title":"Acta Cytologica"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.162"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318257cc1c"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:16:52Z","timestamp":1749010612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dc.25475"],"URL":"https:\/\/doi.org\/10.1002\/dc.25475","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"2025-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}